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Literature summary for 3.4.24.B10 extracted from

  • Cui, D.; Arima, M.; Takubo, K.; Kimura, T.; Horiuchi, K.; Minagawa, T.; Matsuda, S.; Ikeda, E.
    ADAM12 and ADAM17 are essential molecules for hypoxia-induced impairment of neural vascular barrier function (2015), Sci. Rep., 5, 12796 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.B10

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Mus musculus 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
claudin-5 + H2O Mus musculus
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q61824
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bEnd3 cell
-
 Mus musculus
-
brain microvascular endothelial cell
-
 Mus musculus
-
endothelial cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
claudin-5 + H2O
-
 Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
a disintegrin and metalloprotease 12
-
 Mus musculus
ADAM12
-
 Mus musculus

General Information

General Information Comment Organism
malfunction enzyme inhibition is sufficient to rescue the in vivo neural vasculature under hypoxia from the loss of barrier function Mus musculus
physiological function the enzyme is an essential molecules for hypoxia-induced impairment of neural vascular barrier function Mus musculus