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Literature summary for 3.4.24.B10 extracted from

  • Aghababaei, M.; Hogg, K.; Perdu, S.; Robinson, W.P.; Beristain, A.G.
    ADAM12-directed ectodomain shedding of E-cadherin potentiates trophoblast fusion (2015), Cell Death Differ., 22, 1970-1984.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.B10

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
68000
-
 x * 68000, mature enzyme, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
E-cadherin + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O43184
-
-

Source Tissue

Source Tissue Comment Organism Textmining
BeWo cell
-
 Homo sapiens
-
chorionic villus
-
 Homo sapiens
-
trophoblast
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
E-cadherin + H2O
-
 Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
? x * 68000, mature enzyme, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
ADAM12
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens ADAM12 is dynamically upregulated and under the transcriptional control of protein kinase A up

General Information

General Information Comment Organism
malfunction enzyme loss impedes spontaneous fusion of primary cytotrophoblasts Homo sapiens
physiological function the enzyme controls trophoblast fusion through E-cadherin ectodomain shedding and remodeling of intercellular boundaries Homo sapiens