EC Number   |
General Information |
Reference  |
|---|
   3.5.4.B9 | physiological function |
the enzyme causes C to T mutations in the cDNA copy of the HIV-1 genome |
719342 |
| 3.5.4.B9 | physiological function |
the single-stranded DNA-dependent cytosine deaminase inactivates HIV-1 in T cells by C to T hypermutation |
720014 |
| 3.5.4.B9 | physiological function |
the enzyme is capable of blocking retrovirus replication by editing viral cDNA and impairing reverse transcription |
721668 |
| 3.5.4.B9 | physiological function |
the enzyme causes mutational diversity by initiating mutations on regions of single-stranded DNA. The enzyme enters the cytoplasm of the targeted T cell and catalyzes C deaminations on reverse transcribed cDNA causing HIV-1 retroviral inactivation. Enzyme-initiated mutations boost human fitness and restricts HIV-1 replication in the absence of the viral infectivity factor. The enzyme is involved in hepatic metastasis of colorectal cancer |
721999 |
| 3.5.4.B9 | physiological function |
the enzyme is a single-stranded DNA cytosine deaminase that functions in innate immunity against retroviruses and retrotransposons. The enzyme can potently restrict virus infectivity factor-deficient HIV-1 replication by catalyzing excessive levels of G->A hypermutation. Sublethal levels of enzyme-catalyzed mutation may contribute to the high level of HIV-1 fitness and its incurable prognosis |
722064 |
| 3.5.4.B9 | physiological function |
the enzyme inhibits HIV replication and inhibits retroviral infection by deaminating first strand cDNA, generating viral DNA mutations and potential viral elimination |
722103 |
| 3.5.4.B9 | physiological function |
the enzyme exhibits anti-human immunodeficiency virus-1 (HIV-1) activity by deaminating cytidines of the minus strand of HIV-1. Virus infectivity factor of HIV-1 counteracts the anti-HIV-1 activity of the enzyme |
722114 |
| 3.5.4.B9 | physiological function |
the enzyme restricts replication of HIV-1 by inducing viral genome mutagenesis through deamination of cytosine to uracil on HIV-1 cDNA processively through jumping and sliding. The jumping and sliding of Apo3G is needed for efficient mutational inactivation of HIV-1 |
722698 |
| 3.5.4.B9 | physiological function |
the enzyme is an important component of the cellular innate immune response to retroviral infection. The enzyme APOBEC3G can extinguish HIV-1 infectivity by its incorporation into virus particles and subsequent cytosine deaminase activity that attacks the nascent viral cDNA during reverse transcription, causing lethal mutagenesis. The enzyme can also induce sublethal mutagenesis, which maintains virus infectivity and contribute to HIV-1 variation |
723071 |
| 3.5.4.B9 | physiological function |
the enzyme is encapsulated by the HIV virion and facilitates restriction of HIV-1 infection in T cells by deaminating cytosines in nascent minus-strand complementary DNA |
723256 |
