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Literature summary for 3.5.4.B9 extracted from

  • Sadler, H.A.; Stenglein, M.D.; Harris, R.S.; Mansky, L.M.
    APOBEC3G contributes to HIV-1 variation through sublethal mutagenesis (2012), J. Virol., 84, 7396-7404.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HEK-293 cells Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cytosine in single-stranded viral DNA + H2O Homo sapiens
-
uracil in single-stranded viral DNA + NH3
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cytosine in single-stranded viral DNA + H2O
-
Homo sapiens uracil in single-stranded viral DNA + NH3
-
?

Synonyms

Synonyms Comment Organism
A3G
-
Homo sapiens
APOBEC3G
-
Homo sapiens

General Information

General Information Comment Organism
physiological function the enzyme is an important component of the cellular innate immune response to retroviral infection. The enzyme APOBEC3G can extinguish HIV-1 infectivity by its incorporation into virus particles and subsequent cytosine deaminase activity that attacks the nascent viral cDNA during reverse transcription, causing lethal mutagenesis. The enzyme can also induce sublethal mutagenesis, which maintains virus infectivity and contribute to HIV-1 variation Homo sapiens