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Results 1 - 10 of 16 > >>
EC Number General Information Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.5.4.B9metabolism the APOBEC3 family has many roles, such as restricting endogenous and exogenous retrovirus replication and retrotransposon insertion events and reducing DNA-induced inflammation 755694
Display the word mapDisplay the reaction diagram Show all sequences 3.5.4.B9metabolism the enzyme generates cytidine to deoxyuridine mutations in single-stranded DNA, and is capable of restricting replication of HIV-1 by generating mutations in viral genome 757774
Display the word mapDisplay the reaction diagram Show all sequences 3.5.4.B9physiological function APOBEC3G is a single-stranded DNA cytidine deaminase capable of restricting retroviral replication 723285
Display the word mapDisplay the reaction diagram Show all sequences 3.5.4.B9physiological function APOBEC3G protein inhibits HCV replication through direct binding at non-structural protein NS3 at its C-terminus, which is responsible for NS3's helicase and NTPase activities 735015
Display the word mapDisplay the reaction diagram Show all sequences 3.5.4.B9physiological function the enzyme causes C to T mutations in the cDNA copy of the HIV-1 genome 719342
Display the word mapDisplay the reaction diagram Show all sequences 3.5.4.B9physiological function the enzyme causes mutational diversity by initiating mutations on regions of single-stranded DNA. The enzyme enters the cytoplasm of the targeted T cell and catalyzes C deaminations on reverse transcribed cDNA causing HIV-1 retroviral inactivation. Enzyme-initiated mutations boost human fitness and restricts HIV-1 replication in the absence of the viral infectivity factor. The enzyme is involved in hepatic metastasis of colorectal cancer 721999
Display the word mapDisplay the reaction diagram Show all sequences 3.5.4.B9physiological function the enzyme exhibits anti-human immunodeficiency virus-1 (HIV-1) activity by deaminating cytidines of the minus strand of HIV-1. Virus infectivity factor of HIV-1 counteracts the anti-HIV-1 activity of the enzyme 722114
Display the word mapDisplay the reaction diagram Show all sequences 3.5.4.B9physiological function the enzyme inhibits HIV replication and inhibits retroviral infection by deaminating first strand cDNA, generating viral DNA mutations and potential viral elimination 722103
Display the word mapDisplay the reaction diagram Show all sequences 3.5.4.B9physiological function the enzyme is a single-stranded DNA cytosine deaminase that functions in innate immunity against retroviruses and retrotransposons. The enzyme can potently restrict virus infectivity factor-deficient HIV-1 replication by catalyzing excessive levels of G->A hypermutation. Sublethal levels of enzyme-catalyzed mutation may contribute to the high level of HIV-1 fitness and its incurable prognosis 722064
Display the word mapDisplay the reaction diagram Show all sequences 3.5.4.B9physiological function the enzyme is an endogenous inhibitor of human immunodeficiency virus type 1 (HIV-1) replication, able to induce G to A hypermutation in newly synthesized viral DNA 723260
Results 1 - 10 of 16 > >>