EC Number |
General Information |
Reference |
---|
2.1.1.182 | malfunction |
acquisition of high-level resistance to kasugamycin at an extraordinarily high frequency, ksgA mutants display a disadvantage in overall fitness compared to the parent strain |
701730 |
2.1.1.182 | malfunction |
mutants which contain a frameshift mutation in ksgA are severely impaired for growth |
-, 702903 |
2.1.1.182 | physiological function |
KsgA confers kasugamycin sensitivity to Chlamydia trachomatis and impacts bacterial fitness |
-, 702903 |
2.1.1.182 | malfunction |
spontaneous KSGR mutants in Neisseria gonorrhoeae arise through mutations in ksgA, which are likely to reduce KsgA activity and lead to undermethylated rRNA and thus resistance to kasugamycin |
704036 |
2.1.1.182 | physiological function |
KsgA, in addition to its methyltransferase activity, has another unidentified function that plays a role in the suppression of the cold-sensitive phenotype of the Era(E200K) strain. The additional function may be involved in the acid shock response |
704274 |
2.1.1.182 | malfunction |
yeast enzyme Dim1 complements heterologously for ksgA- mutation in Escherichia coli, demonstrating functional equivalence of the two proteins |
705108 |
2.1.1.182 | malfunction |
loss of this dimethylation confers resistance to the antibiotic kasugamycin |
-, 705141 |
2.1.1.182 | malfunction |
cold sensitivity and altered ribosomal profiles are associated with a DELTAksgA genotype in Escherichia coli |
705774 |
2.1.1.182 | physiological function |
KsgA acts as a ribosome biogenesis factor. KsgA alters 16S rRNA processing and has a critical role is as a supervisor of biogenesis of 30S subunits in vivo |
705774 |
2.1.1.182 | malfunction |
the inability to form dimethyladenine in the 16S rRNA-derived oligonucleotide is accompanied by muatation from kasugamycin sensitivity to resistance |
705859 |