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Literature summary for 2.1.1.182 extracted from

  • Helser, T.L.; Davies, J.E.; Dahlberg, J.E.
    Change in methylation of 16S ribosomal RNA associated with mutation to kasugamycin resistance in Escherichia coli (1971), Nat. New Biol., 233, 12-14.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4 S-adenosyl-L-methionine + adenine1518/adenine1519 in 16S rRNA Escherichia coli
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4 S-adenosyl-L-homocysteine + N6-dimethyladenine1518/N6-dimethyladenine1519 in 16S rRNA
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?

Organism

Organism UniProt Comment Textmining
Escherichia coli
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-
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4 S-adenosyl-L-methionine + adenine1518/adenine1519 in 16S rRNA
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Escherichia coli 4 S-adenosyl-L-homocysteine + N6-dimethyladenine1518/N6-dimethyladenine1519 in 16S rRNA
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?
4 S-adenosyl-L-methionine + adenine1518/adenine1519 in 16S rRNA dimethylates the adenine residues in 16S rRNA-derived oligonucleotide with the specific sequence AACCUG Escherichia coli 4 S-adenosyl-L-homocysteine + N6-dimethyladenine1518/N6-dimethyladenine1519 in 16S rRNA
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?

General Information

General Information Comment Organism
malfunction the inability to form dimethyladenine in the 16S rRNA-derived oligonucleotide is accompanied by muatation from kasugamycin sensitivity to resistance Escherichia coli