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EC Number General Information Commentary Reference
Display the reaction diagram Show all sequences 2.1.1.182malfunction acquisition of high-level resistance to kasugamycin at an extraordinarily high frequency, ksgA mutants display a disadvantage in overall fitness compared to the parent strain 701730
Display the reaction diagram Show all sequences 2.1.1.182malfunction cold sensitivity and altered ribosomal profiles are associated with a DELTAksgA genotype in Escherichia coli 705774
Display the reaction diagram Show all sequences 2.1.1.182physiological function knockout of KsgA attenuates the killing ability against silkworms. The KsgA knockout strain is sensitive to oxidative stress and has a lower survival rate in murine macrophages than the parent strain. The KsgA knockout strain exhibits decreased translational fidelity in oxidative stress conditions. Administration of N-acetyl-L-cysteine restores the killing ability of the knockout strain against silkworms -, 756118
Display the reaction diagram Show all sequences 2.1.1.182physiological function KsgA acts as a ribosome biogenesis factor. KsgA alters 16S rRNA processing and has a critical role is as a supervisor of biogenesis of 30S subunits in vivo 705774
Display the reaction diagram Show all sequences 2.1.1.182physiological function KsgA confers kasugamycin sensitivity to Chlamydia trachomatis and impacts bacterial fitness -, 702903
Display the reaction diagram Show all sequences 2.1.1.182physiological function KsgA has a DNA glycosylase/AP lyase activity for C mispaired with oxidized T that prevents the formation of mutations, which is in addition to its rRNA adenine methyltransferase activity essential for ribosome biogenesis 705968
Display the reaction diagram Show all sequences 2.1.1.182physiological function KsgA, in addition to its methyltransferase activity, has another unidentified function that plays a role in the suppression of the cold-sensitive phenotype of the Era(E200K) strain. The additional function may be involved in the acid shock response 704274
Display the reaction diagram Show all sequences 2.1.1.182malfunction loss of this dimethylation confers resistance to the antibiotic kasugamycin -, 705141
Display the reaction diagram Show all sequences 2.1.1.182malfunction mutants which contain a frameshift mutation in ksgA are severely impaired for growth -, 702903
Display the reaction diagram Show all sequences 2.1.1.182malfunction spontaneous KSGR mutants in Neisseria gonorrhoeae arise through mutations in ksgA, which are likely to reduce KsgA activity and lead to undermethylated rRNA and thus resistance to kasugamycin 704036
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