EC Number   |
Expression |
Reference |
|---|
    5.3.99.4 | down |
a dramatic loss in PGIS mRNA levels is observed in primary lung tumor samples |
702474 |
| 5.3.99.4 | down |
after 16 weeks the prostacyclin synthase mRNA levels are reduced |
701992 |
| 5.3.99.4 | down |
enzyme expression, in terms of mRNA and protein, are lower in tumour samples than in non-tumoural mucosa |
748449 |
| 5.3.99.4 | down |
hyperglycemia and palmitate increase prostacyclin synthase nitration and reduce its activity |
701619 |
| 5.3.99.4 | down |
the enzyme expression is downregulated in several types of cancer |
749211 |
| 5.3.99.4 | more |
interleukin-1beta (10 ng/ml, 24 h incubation) does not alter PGIS protein expression |
715791 |
| 5.3.99.4 | up |
after 8 weeks on fat diet, aortic arches from low-density lipoprotein receptor deficient, LDL r-KO, mice shows a significant increase in prostacyclin synthase levels |
701992 |
| 5.3.99.4 | up |
angiotensin II (0.1 mM, 24 h incubation) induces PGIS mRNA expression. Pretreatment with losartan (0.01 mM), PD98059 (0.025 mM) or SB203580 (0.01 mM) prevents PGIS protein expression induced by the combination of angiotensin II and interleukin-1beta |
715791 |
| 5.3.99.4 | up |
for overexpression of prostacyclin synthase transgenic mice, carrying the rat prostacyclin synthase gene, are developed |
705476 |
| 5.3.99.4 | up |
PGIS mRNA and protein expression is increased in response to mechanical cyclical stretch in both spinal ligament and uterine myometrial cells, up-regulation is observed in umbilical vein endothelial cell treated with a thromboxane analogue |
702474 |
