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Literature summary for 5.3.99.4 extracted from

  • Galan, M.; Miguel, M.; Beltran, A.E.; Rodriguez, C.; Garcia-Redondo, A.B.; Rodriguez-Calvo, R.; Alonso, M.J.; Martinez-Gonzalez, J.; Salaices, M.
    Angiotensin II differentially modulates cyclooxygenase-2, microsomal prostaglandin E2 synthase-1 and prostaglandin I2 synthase expression in adventitial fibroblasts exposed to inflammatory stimuli (2011), J. Hypertens., 29, 529-536.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Prostaglandin H2 Rattus norvegicus
-
Prostaglandin I2
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
aortic adventitial fibroblast
-
Rattus norvegicus
-
HAoAF cell
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Prostaglandin H2
-
Rattus norvegicus Prostaglandin I2
-
?

Synonyms

Synonyms Comment Organism
PGI2 synthase
-
Rattus norvegicus
PGIS
-
Rattus norvegicus
Prostaglandin I2 synthase
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
heme
-
Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus interleukin-1beta (10 ng/ml, 24 h incubation) does not alter PGIS protein expression additional information
Rattus norvegicus angiotensin II (0.1 mM, 24 h incubation) induces PGIS mRNA expression. Pretreatment with losartan (0.01 mM), PD98059 (0.025 mM) or SB203580 (0.01 mM) prevents PGIS protein expression induced by the combination of angiotensin II and interleukin-1beta up