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Literature summary for 5.3.99.4 extracted from
- The role of prostacyclin synthase and thromboxane synthase signaling in the development and progression of cancer (2010), Biochim. Biophys. Acta, 1805, 153-166.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| interleukin-1 | - |
Homo sapiens | |
| interleukin-6 | - |
Homo sapiens |  |
| TNFalpha | - |
Homo sapiens |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | prostacyclin synthase may be chemopreventive in cancer | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| rofecoxib | - |
Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
| nuclear membrane | - |
Homo sapiens | 31965 | - |
| plasma membrane | - |
Homo sapiens | 5886 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 52000 | - |
- |
Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Prostaglandin H2 | Homo sapiens | - |
Prostaglandin I2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| lung cancer cell | - |
Homo sapiens | - |
| myometrial cell | - |
Homo sapiens | - |
| neuron | - |
Homo sapiens | - |
| smooth muscle cell | - |
Homo sapiens | - |
| umbilical vein endothelial cell | - |
Homo sapiens | - |
| vascular endothelial cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Prostaglandin H2 | - |
Homo sapiens | Prostaglandin I2 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| prostacyclin synthase | - |
Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | a dramatic loss in PGIS mRNA levels is observed in primary lung tumor samples | down |
| Homo sapiens | PGIS mRNA and protein expression is increased in response to mechanical cyclical stretch in both spinal ligament and uterine myometrial cells, up-regulation is observed in umbilical vein endothelial cell treated with a thromboxane analogue | up |
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Release 2023.1 (January 2023)
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