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Literature summary for 5.3.99.4 extracted from

  • Keith, R.L.; Karoor, V.; Mozer, A.B.; Hudish, T.M.; Le, M.; Miller, Y.E.
    Chemoprevention of murine lung cancer by gefitinib in combination with prostacyclin synthase overexpression (2010), Lung Cancer, 70, 37-42.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.3.99.4

Application

Application Comment Organism
medicine it is hypothesized that the combination of prostacyclin synthase overexpression and epidermal growth factor receptor tyrosine kinase inhibitor, EGFR TKI, would lead to augmented chemoprevention for lung cancer Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Prostaglandin H2 Mus musculus
-
 Prostaglandin I2
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 transgenic mice are developed using a construct consisting of the human SP-C promotor and full-length rat prostacyclin synthase cDNA
-

Source Tissue

Source Tissue Comment Organism Textmining
lung
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Prostaglandin H2
-
 Mus musculus Prostaglandin I2
-
 ?

Synonyms

Synonyms Comment Organism
PGIS
-
 Mus musculus
prostacyclin synthase
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus for overexpression of prostacyclin synthase transgenic mice, carrying the rat prostacyclin synthase gene, are developed up