EC Number   |
Posttranslational Modification  |
Reference |
|---|
   3.1.3.53 | phosphoprotein |
- |
646357 |
| 3.1.3.53 | phosphoprotein |
130/133 kDa myosin-binding subunits M130/M133 and 20 kDa regulatory subunit M20 are phosphorylated by protein kinase A to 3 and 1 mol phosphate/mol of subunit, phosphorylation of holoenzyme decreases phospholipid binding, M130/133: C-terminal phosphorylation site involved in regulation of phospholipid binding, no phosphorylation of the catalytic subunit PP-1cdelta, protein kinase C also phosphorylates M130/M133 and M20, but no effect on binding of phospholipids |
646357 |
| 3.1.3.53 | phosphoprotein |
Ca2+-desensitizing hypoxic relaxation requires dephosphorylation of myosin phosphatase regulatory subunit |
666160 |
| 3.1.3.53 | phosphoprotein |
inhibition of enzyme activity by phosphorylation of its myosin-targeting subunit, only in adult gizzard, not in adult aortic smooth muscle, phosphorylation is not required for Ca2+ sensitization of force |
646360 |
| 3.1.3.53 | phosphoprotein |
large subunit MYPT1: phosphorylation site Thr-695, potential site for phosphorylation by protein kinase A is Thr-853 |
646371 |
| 3.1.3.53 | phosphoprotein |
myosin light chain phosphatase is regulated by phosphorylation of the catalytic subunit |
715547 |
| 3.1.3.53 | phosphoprotein |
myosin-binding subunit of MLCP is phosphorylated at Thr-641 and Thr-799 by Rho kinase to 2 mol phosphate/mol of MBS |
646366 |
| 3.1.3.53 | phosphoprotein |
MYPT1 is cleaved by caspase-3 at Asp-884 in apoptotic cells, and the cleaved MYPT1 is strongly phosphorylated at Thr-696 and Thr-853, phosphorylation of which is known to inhibit myosin II binding |
732482 |
| 3.1.3.53 | phosphoprotein |
Par-1 (cell polarity protein) activates Myo-II by phosphorylating and inhibiting the myosin phosphatase complex |
731688 |
| 3.1.3.53 | phosphoprotein |
phosphorylation at Thr-695 of the MLCP regulatory subunit MYPT1 inhibits MLCP activity, Thr-695 phosphorylation is independent of stimulation of G-proteins, Rho-kinase or protein kinase C, MYPT1 can also be phosphorylated at Thr-850, which is a non-inhibitory Rho-kinase site, Thr-850 phosphorylation is activated by G-proteins |
646356 |
