EC Number   |
Application |
Reference |
|---|
    2.7.1.1 | analysis |
detection of glucose-induced conformational change in hexokinase II using fluorescence complementation assay |
672756 |
| 2.7.1.1 | analysis |
high-throughput assay for screening small molecule collections to identify inhibitors of the Plasmodium falciparum hexokinase. The assay employs an ADP-GloTM reporter system in a 1536-well plate format, is robust with a signal-to-background of 3.4, a percent coefficient of variation of 6.8 and a Z'-factor of 0.75 |
737463 |
| 2.7.1.1 | diagnostics |
increased proportion of hexokinase II is used as a marker for brain tumors |
640259 |
| 2.7.1.1 | industry |
production of abundant intermediates for industrially erythritol production |
-, 704746 |
| 2.7.1.1 | medicine |
28-homobrassinolide is able to protect or restore the native structure of hexokinase when exposed to diabetic levels of glucose |
738893 |
| 2.7.1.1 | medicine |
activation of glucokinase as glucose lowering therapy for type 2 diabetes |
703597 |
| 2.7.1.1 | medicine |
endogenous glucokinase expression correlates with O-GlcNAc levels in the pathophysiological model of type II diabetes, ob/ob mice. In response to the pharmacological inhibition of O-GlcNAcase, contents of glucokinase increase. Glucokinase is modified by O-GlcNAcylation. siRNA-mediated O-linked N-acetylglucosamine transferase knock-down not only decreases O-GlcNAc content but also glucokinase protein level |
737623 |
| 2.7.1.1 | medicine |
given the combined prominent role of glucokinase on insulin secretion and hepatic glucose metabolism where the GK-GKRP mechanism is involved, activation of glucokinase has a new therapeutic potential in the treatment of type 2 diabetes |
674716 |
| 2.7.1.1 | medicine |
glucokinase is a potential therapeutic target for treating maturity-onset diabetes of the young and persistent hyperinsulinemic hypoglycemia of infancy |
706430 |
| 2.7.1.1 | medicine |
glucokinase mutations are found only in medically responsive children with congenital hyperinsulinism who are negative for ABCC8 and KCNJ11 mutations |
686512 |
