Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | the allosteric activator compound A, increases the level of cytoplasmic glucokinase in both isolated rat primary hepatocytes and the liver tissues from rats. Compound A interacts with glucose-bound free GK, thereby impairing the association of glucokinase and glucokinase regulatory protein | Rattus norvegicus |
Application | Comment | Organism |
---|---|---|
medicine | given the combined prominent role of glucokinase on insulin secretion and hepatic glucose metabolism where the GK-GKRP mechanism is involved, activation of glucokinase has a new therapeutic potential in the treatment of type 2 diabetes | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
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Rattus norvegicus | - |
- |
- |