EC Number |
Application |
Reference |
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1.3.1.24 | more |
potential role in the insulin signaling pathway, BVR is both a substrate for insulin receptor tyrosine kinase activity and a kinase for serine phosphorylation of insulin receptor substrate 1 |
666747 |
1.3.1.24 | medicine |
BVR may represent a novel strategy for the treatment of multiple sclerosis and other oxidative stress-mediated diseases, treatment with BVR ameliorates both clinical and pathological signs of autoimmune encephalomyelitis more efficiently than treatments with traditional antioxidant enzymes |
673797 |
1.3.1.24 | more |
potential function in propagation of signals relayed through protein kinase C, binds to protein kinase C betaII, increases its phosphorylation, and is a substrate for the kinase, increases PMA-dependent c-fos activation and protein kinase C translocation to the membrane |
674899 |
1.3.1.24 | more |
BVR regualtes cellular levels of biliverdin, a potent gene regulator and determinant factor for dorsal axis development in Xenopus larva |
676353 |
1.3.1.24 | more |
interacts with the insulin receptor kinase domain, key factor in the MAPK pathway and the PI3K pathway as well as regulating PKC isoforms that link the two pathways, plays a role in the mechanism of insulin resistance |
676353 |
1.3.1.24 | more |
regulates oxidative response and HO-1 expression |
676353 |
1.3.1.24 | medicine |
hyperbiliverdinaemia, green jaundice, with green plasma and urine may be caused by a genetic defect in the BVR-A gene in conjunction with decompensated liver cirrosis |
699950 |
1.3.1.24 | medicine |
data gathered to date have identified the potential utility of hBVR in modulating cell signaling and the wide range of functions that are regulated by protein kinases that include growth, differentiation, gene transcription and metabolism, regulation of glucose uptake, induction of HO-1, and cytokine and Toll-like receptor signaling are potential target candidates for hBVR-based therapeutic strategies |
701357 |
1.3.1.24 | medicine |
therapeutic potential of human BVR and human HVR-based peptides by affecting the MAPK signaling pathways, overview |
711795 |
1.3.1.24 | medicine |
finding that BVR and HO-2 levels, myocyte apoptosis, and contractile function of the heart can be modulated by small human BVR-based peptides offers a promising therapeutic approach for treatment of cardiac dysfunctions |
711965 |