EC Number   |
Localization |
GeneOntology No. |
Reference |
|---|
   7.6.2.8 | lysosomal membrane |
translocation of the ABC transporter ABCD4 from the endoplasmic reticulum to lysosomes requires the escort protein LMBD1 |
GO:0005765 AmiGO QuickGO |
752200 |
| 7.6.2.8 | membrane |
- |
GO:0016020 AmiGO QuickGO |
734003, 734820, 751661, 752215 |
| 7.6.2.8 | membrane |
integral membrane enzyme |
GO:0016020 AmiGO QuickGO |
-, 750412 |
| 7.6.2.8 | membrane |
periplasmic and cytosolic orientation |
GO:0016020 AmiGO QuickGO |
697950 |
| 7.6.2.8 | membrane |
periplasmic orientation |
GO:0016020 AmiGO QuickGO |
696776 |
| 7.6.2.8 | membrane |
transmembrane enzyme |
GO:0016020 AmiGO QuickGO |
-, 749978 |
| 7.6.2.8 | more |
ABCD4 barely interacts with the peroxisomal biogenesis factor Pex19p, because of its lack of NH2-terminal hydrophobic motif. As a result, the transmembrane domain (TMD) 1 of ABCD4 is recognized by certain signal recognition particles and integrated into the ER membrane. ABCD4 dimer then makes a complex with lysosomal membrane protein LMBD1, an adopter protein, and targets to lysosome |
- |
749821 |
| 7.6.2.8 | more |
LMBD1 associates with ABCD4 at the ER membrane and transports ABCD4 to lysosomes, ABCD4 interacts with LMBD1. The translocation depends on the lysosomal targeting ability of LMBD1. Endogenous ABCD4 is localized to both lysosomes and the endoplasmic reticulum. ABCD4 lacks the NH2-teminal hydrophobic region that is responsible for the targeting to peroxisomes. ABCD4 and LMBD1 form complex in vitro. The regions around transmembrane helix 2 and 5 of ABCD4 are critically important for the translocation of ABCD4 to lysosomes along with LMBD1 |
- |
752200 |
| 7.6.2.8 | periplasm |
- |
- |
667642, 685066, 685614, 685626, 690056, 751661 |
| 7.6.2.8 | periplasm |
btuE |
- |
210326, 210329 |
