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EC Number
Activating Compound
Commentary
Reference
DNA
absolute requirement
GDP
increases activity in absence of Mg2+
GTP
increases activity in absence of Mg2+
GTP(gammaS)
increases activity in absence of Mg2+
ATP
5-10 mM, 20-30% stimulation
4-[[[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl](pyridin-2-ylsulfonyl)amino]methyl]-N,N-dimethylpiperidine-1-carboxamide
activates in presence of Mg2+, inhibits in absence of Mg2+
harmaline hydrochloride
activates more strongly in absence of Mg2+ than in presence of Mg2+
Phthalic acid
activates more strongly in absence of Mg2+ than in presence of Mg2+
DNA
required
DNA
the enzyme is completely dependent on the presence of DNA containing single or double stranded breaks. Activation results in a decondensation of chromatin superstructure in vitro, which is caused mainly by hyper(ADP-ribosyl)ation of histone H1
Results 1 - 10 of 25 > >>