EC Number   |
Activating Compound |
Reference  |
|---|
    2.4.2.30 | DNA |
enzyme has an N-terminal binding domain |
638000 |
| 2.4.2.30 | more |
in native conformation, CRM66 shows limited ability to modify EF-2 covalently. Upon activation with urea and dithiothreitol CRM66 loses ADP-ribosylation activity entirely, yet it retains the ability to bind NAD+. Replacement of Tyr-426 with histidine in CRM66 completely restores cytotoxicity and ADP-ribosyltransferase activity |
662087 |
| 2.4.2.30 | FAS |
exoenzyme S absolutely requires a soluble eukaryotic protein, named FAS (Factor Activating exoenzyme E), in order to ADP-ribosylate all substrates. In the presence of FAS, exoenzyme S ADP-ribosylates several proteins in lysates of Pseudomonas aeruginosa. Purification and characterization of FAS |
662089 |
| 2.4.2.30 | more |
PARP-1 is activated in response to DNA damage and participates in DNA repair, genomic integrity and cell death |
671255 |
| 2.4.2.30 | more |
stable expression of the transcription factor tonicity-responsive enhancer/osmotic response element-binding protein, TonEBP/OREBP, clone KIAA0827/amino acids 1-547, in HEK-293 cells increases the expression of the enzyme |
671265 |
| 2.4.2.30 | more |
DNA binding by PARP-1 triggers its activity and it adds poly(ADP-ribose) polymers to itself and to surrounding histones, overview |
672969 |
| 2.4.2.30 | protein 14-3-3 |
dependent on |
672996 |
| 2.4.2.30 | protein 14-3-3 |
required, interaction analysis, interaction equires residues L426, D427, and L428, overview, binding study of mutant enzymes, overview |
673573 |
| 2.4.2.30 | 3-amino-1-methyl-5H-pyrido[4,3-b]indole |
i.e. Trp-P-2, 34% activation at 1 mM, 7% inhibition at 5 mM, IC50: 2.2 mM |
675627 |
| 2.4.2.30 | Bmh1p |
a yeast homologue of the human FAS, acts as an activating ExoS cofactor, overview |
694800 |
