2.4.2.30 DNA absolute requirement 637991, 637993 2.4.2.30 GDP increases activity in absence of Mg2+ 637994 2.4.2.30 GTP increases activity in absence of Mg2+ 637994 2.4.2.30 GTP(gammaS) increases activity in absence of Mg2+ 637994 2.4.2.30 ATP 5-10 mM, 20-30% stimulation 637995 2.4.2.30 4-[[[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl](pyridin-2-ylsulfonyl)amino]methyl]-N,N-dimethylpiperidine-1-carboxamide activates in presence of Mg2+, inhibits in absence of Mg2+ 637997 2.4.2.30 harmaline hydrochloride activates more strongly in absence of Mg2+ than in presence of Mg2+ 637997 2.4.2.30 Phthalic acid activates more strongly in absence of Mg2+ than in presence of Mg2+ 637997 2.4.2.30 DNA required 637998 2.4.2.30 DNA the enzyme is completely dependent on the presence of DNA containing single or double stranded breaks. Activation results in a decondensation of chromatin superstructure in vitro, which is caused mainly by hyper(ADP-ribosyl)ation of histone H1 637999