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Gene ontology
Version 2014-12-22
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Details for plasma kallikrein-kinin cascade
Gene ontology ID
GO:0002353
Definition
A series of reactions that takes place outside the cell occurring in response to tissue damage and initiated within blood plasma by the action of activated Factor XII (Hageman Factor) on prekallikrein to convert it to plasma kallikrein, and the subsequent reaction of plasma kallikrein with high molecular weight kininogen. The ultimate product of the plasma kallikrein-kinin cascade is bradykinin, an agent known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability
References
1. GOC: add
2. ISBN 0721601871
3. PMID 11842287
4. PMID 14501145
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