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Information on EC 4.6.1.2 - guanylate cyclase and Organism(s) Caenorhabditis elegans and UniProt Accession Q9GYQ4

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EC Tree
IUBMB Comments
Also acts on ITP and dGTP.
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This record set is specific for:
Caenorhabditis elegans
UNIPROT: Q9GYQ4
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The taxonomic range for the selected organisms is: Caenorhabditis elegans
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
guanylate cyclase, soluble guanylate cyclase, guanylyl cyclase, soluble guanylyl cyclase, npr-a, npr-b, particulate guanylate cyclase, h-nox, no receptor, guanylyl cyclase c, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
receptor-type guanylyl cyclase
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ANPRA
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ANPRB
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Atrial natriuretic peptide A-type receptor
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Atrial natriuretic peptide B-type receptor
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guanyl cyclase
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Guanylate cyclase
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Guanylate cyclase 2D, retinal
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Guanylate cyclase 2E
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Guanylate cyclase 2F, retinal
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Guanylate cyclase, olfactory
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guanylyl cyclase
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hSTAR
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Intestinal guanylate cyclase
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KSGC
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receptor-type guanylyl cyclase
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Rod outer segment membrane guanylate cyclase
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ROS-GC
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ROS-GC2
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soluble guanylyl cyclase
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STA receptor
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
P-O bond cleavage
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PATHWAY SOURCE
PATHWAYS
SYSTEMATIC NAME
IUBMB Comments
GTP diphosphate-lyase (cyclizing; 3',5'-cyclic-GMP-forming)
Also acts on ITP and dGTP.
CAS REGISTRY NUMBER
COMMENTARY hide
9054-75-5
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
GTP
3',5'-cyclic GMP + diphosphate
show the reaction diagram
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regulation of intracellular cGMP concentration is essential for normal thermotaxis
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?
GTP
3',5'-cyclic GMP + diphosphate
show the reaction diagram
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regulation of intracellular cGMP concentration is essential for normal thermotaxis
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?
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
TEMPERATURE RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
variety Bristol (N2)
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
expressed specifically in the AFD thermosensory neurons
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
GCY8_CAEEL
1152
1
129070
Swiss-Prot
Secretory Pathway (Reliability: 1)
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
heterodimer
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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
full-length genomic gcy gene sequence fused to the GFP gene and injected into wild-type animals
full-length genomic gcy gene sequence fused to the GFP gene and injected into wild-type animals
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
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residues H104, Y140, the YxS/TxR motif and missing cysteines Cys78 and Cys214 are conserved in all the insect atypical sGC subunits
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Inada, H.; Ito, H.; Satterlee, J.; Sengupta, P.; Matsumoto, K.; Mori, I.
Identification of guanylyl cyclases that function in thermosensory neurons of Caenorhabditis elegans
Genetics
172
2239-2252
2006
Caenorhabditis elegans, Caenorhabditis elegans (Q9GYQ4)
Manually annotated by BRENDA team
Vermehren, A.; Langlais, K.K.; Morton, D.B.
Oxygen-sensitive guanylyl cyclases in insects and their potential roles in oxygen detection and in feeding behaviors
J. Insect Physiol.
52
340-348
2006
Anopheles gambiae, Apis mellifera, Bombyx mori, Caenorhabditis elegans, Drosophila melanogaster, Drosophila pseudoobscura, Manduca sexta, Tribolium castaneum, Caldanaerobacter subterraneus subsp. tengcongensis
Manually annotated by BRENDA team