EC Number   |
Activating Compound |
Reference |
|---|
   4.6.1.2 | (R)-3',5-dihydroxy-4',7-dimethoxyspiro(2H-1-benzopyran-3(4H)-7'-bicyclo[4.2.0]-octa[1,3,5]-trien)4-one |
activates the soluble guanylate cyclase exhibiting a vasorelaxing effect on the aortic ring, the compound is isolated from bulbs of South African Hyacinthaceae, i.e. Drimiopsis maculata, Eucomis schiffii, Urginea epigea, Drimia altissima, mass spectrometric identification. The compound counteracts vasocontractory agents, overview |
693812 |
| 4.6.1.2 | (Z)-1-(N,N-diethylamino)diazen-1-ium-1,2-diolate |
sGC ferrous-nitrosyl complex adopts two 5-coordinate conformations, a lower activity closed form, which releases NO slowly, and a higher activity open form, which releases NO rapidly |
680895 |
| 4.6.1.2 | 1-benzyl-3-(hydroxymethyl-2-furyl)indazole |
trivial name YC-1, allosteric activator, synergistically increases the catalytic activity in the presence of NO |
650243 |
| 4.6.1.2 | 2'-deoxy-3'-GMP |
the addition of the effector to CO-activated enzyme causes the original 6-coordinate CO-heme to convert to an end product that is an equimolar mixture of a 5- and a new 6-coordinate CO-heme |
747134 |
| 4.6.1.2 | 2'-deoxy-ATP |
poor allosteric activator |
730957 |
| 4.6.1.2 | 2'-deoxy-GTP |
poor allosteric activator |
730957 |
| 4.6.1.2 | 2,2-diethyl-1-nitroso-oxyhydrazine |
0.1 mM, 87fold increase in activity, NO-relasing substance |
649804 |
| 4.6.1.2 | 2,2-diethyl-1-nitroso-oxyhydrazine |
70-80% activation at 0.01 mM in presence of 2 mM GSH |
694270 |
| 4.6.1.2 | 2,2-diethyl-1-nitroso-oxyhydrazine |
NO donor, 0.1 mM, 242fold activation |
652369 |
| 4.6.1.2 | 2-(N,N-diethylamino)-diazenolate-2-oxide |
stimulates 4.3fold |
682023 |
