Literature summary for 4.6.1.2 extracted from

Makino, R.; Obata, Y.; Tsubaki, M.; Iizuka, T.; Hamajima, Y.; Kato-Yamada, Y.; Mashima, K.; Shiro, Y.
Mechanistic insights into the activation of soluble guanylate cyclase by carbon monoxide a multistep mechanism proposed for the BAY 41-2272 induced formation of 5-coordinate CO-heme (2018), Biochemistry, 57, 1620-1631 .

Search for more literature for 4.6.1.2

Activating Compound

Activating Compound	Comment	Organism	Structure
2'-deoxy-3'-GMP	the addition of the effector to CO-activated enzyme causes the original 6-coordinate CO-heme to convert to an end product that is an equimolar mixture of a 5- and a new 6-coordinate CO-heme	Bos taurus
BAY 41-2272	the addition of the effector to CO-activated enzyme causes the original 6-coordinate CO-heme to convert to an end product that is an equimolar mixture of a 5- and a new 6-coordinate CO-heme	Bos taurus
CO	ferrous soluble guanylate cyclase binds CO as two reversible steps. The primary step leads to the full conversion of the ferrous enzyme to the 6-coordinate CO-heme, followed by the slower second step leading to a partial conversion of the 6-coordinate CO-heme to the 5-coordinate CO-heme. Reaction may folow a multistep mechanism, in which the 5-coordinate CO-heme is led by CO release from a putative bis-carbonyl intermediate that is likely provided by the binding of a second CO to the 6-coordinate CO-heme	Bos taurus
Foscarnet	the addition of the effector to CO-activated enzyme causes the original 6-coordinate CO-heme to convert to an end product that is an equimolar mixture of a 5- and a new 6-coordinate CO-heme	Bos taurus

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
from lung tissue	Bos taurus

Source Tissue

Source Tissue	Comment	Organism	Textmining
lung	-	Bos taurus	-

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)