EC Number   |
Protein Variants |
Reference |
|---|
   4.6.1.2 | alpha1L211A |
site-directed mutagenesis of the alpha1 subunit |
693096 |
| 4.6.1.2 | alpha1Y223A |
site-directed mutagenesis |
693096 |
| 4.6.1.2 | C122A |
site-directed mutagenesis of the aldosterone modification site, the mutant is insensitive to inhibition by aldosterone or H2O2 |
693256 |
| 4.6.1.2 | C238S |
no change in cGMP production |
650243 |
| 4.6.1.2 | C243S |
no change in cGMP production |
650243 |
| 4.6.1.2 | C594D |
no 1-benzyl-3-(hydroxymethyl-2-furyl)indazole activation, no synergy with NO |
650243 |
| 4.6.1.2 | C594D/E525K |
loss of activity |
650243 |
| 4.6.1.2 | C594Y |
reduced level of NO and 1-benzyl-3-(hydroxymethyl-2-furyl)indazole activation |
650243 |
| 4.6.1.2 | D100N/D102G |
the mutant shows altered binding of guanylyl cyclase activating protein 1 compared to the wild-type enzyme |
693102 |
| 4.6.1.2 | D102A |
the mutant shows 70% of wild type activity |
714249 |
