EC Number   |
Application |
Reference |
|---|
   4.6.1.2 | analysis |
purified sGC can act as detector for NO-like bioactivity generated from nitrite and glycerol trinitrate and for NO released by heart and liver mitochondria |
694411 |
| 4.6.1.2 | diagnostics |
CT and GA polymorphisms in the 5'-flanking region of the GC-A gene might be useful as susceptibility marker for hypertension |
692585 |
| 4.6.1.2 | drug development |
the soluble guanylate cyclase is a target for compounds used in therapy of heart failure, e.g. nitric oxide-independent, soluble guanylate cyclase activator cinaciguat, BAY 58-2667, that induces vasodilation preferentially in diseased vessels, overview |
693364 |
| 4.6.1.2 | medicine |
antiproliferative mechanisms induced by GCC ligands and exisulind negatively interact in colon cancer cells |
681867 |
| 4.6.1.2 | medicine |
crosstalk occurs between the NO-sGC and atrial natriuretic peptide-pGC pathways to regulate cGMP-dependent vasodilatation in vivo |
-, 678971 |
| 4.6.1.2 | medicine |
different roles of the natriuretic peptide and NO systems. In acute heart failure, the natriuretic peptide system plays a role in maintaining sodium excretion and glomerular filtration rate, while the function of the NO system is in the maintenance of renal blood flow. These two cGMP activating systems function through two distinct GC enzymes, playing a key role in maintaining renal function in acute heart failure |
677487 |
| 4.6.1.2 | medicine |
guanylyl cyclase activity is related to intracellular Ca2+ mobilization and this Ca2+-cGMP cross-talk may in turn be associated with parasite infectivity |
-, 680181 |
| 4.6.1.2 | medicine |
in red blood cells, an intact soluble guanylate cyclaseC/PDE5/PKG-dependent signaling pathway exists, which remains fully responsive to NO and guanylate cyclase stimulators/activators in patients with endothelial dysfunction |
749269 |
| 4.6.1.2 | medicine |
inhibition of sGC is an approach to restore hypoxic pulmonary vasoconstriction during endotoxemia |
709691 |
| 4.6.1.2 | medicine |
limited species differences in sGC subunit distribution of primates and rodents. NO-cGMP signaling pathway may be involved in important brain functions such as memory formation, sensory processing, and behavior |
681090 |
