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Information on EC 4.1.2.61 - feruloyl-CoA hydratase/lyase

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EC Tree
     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.2 Aldehyde-lyases
                4.1.2.61 feruloyl-CoA hydratase/lyase
IUBMB Comments
The enzyme is a member of the enoyl-CoA hydratase/isomerase superfamily. It catalyses a two-step process involving first the hydration of the double bond of feruloyl-CoA and then the cleavage of the resultant beta-hydroxy thioester by retro-aldol reaction. (E)-caffeoyl-CoA and (E)-4-coumaroyl-CoA are also substrates.
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Word Map
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
3-hydroxy-3-(4-hydroxyl-3-methoxyphenyl)propanoyl-CoA vanillin lyase (acetyl-CoA-forming), 4-hydroxycinnamoyl-CoA hydratase/lyase, 4-hydroxycinnamoyl-coenzyme A hydratase-lyase, couA, ECH, enoyl-CoA hydratase/aldolase, enoyl-CoA-hydratase/aldolase, FCHL, FerB, feruloyl-CoA hydratase-lyase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA = vanillin + acetyl-CoA
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(1b); involved, together with EC 4.2.1.101 trans-feruloyl-CoA hydratase, in the production of vanillin from trans-ferulic acid. Vanillin is converted to vanillate by EC 1.2.1.67 vanillin dehydrogenase
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4-hydroxy-3-methoxyphenyl-beta-hydroxypropanoyl-CoA = feruloyl-CoA + H2O
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feruloyl-CoA + H2O = 3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA
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(1a)
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feruloyl-CoA + H2O = vanillin + acetyl-CoA
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overall reaction
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