Ligand feruloyl-CoA

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Basic Ligand Information

Molecular Structure
Picture of feruloyl-CoA (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C31H44N7O19P3S
feruloyl-CoA
GBXZVJQQDAJGSO-NBXNMEGSSA-N
Synonyms:
4-feruloyl-CoA, 4-hydroxy-3-methoxycinnamoyl-CoA, 4-trans-feruloyl-CoA, feruloylCoA, feruloyl CoA, Ferulyl-CoA, trans-feruloyl-CoA


Show all pahtways known for Show all BRENDA pathways known for feruloyl-CoA

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (22 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
trans-feruloyl-CoA + 2-oxoglutarate + O2 = trans-6-hydroxyferuloyl-CoA + succinate + CO2
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trans-feruloyl-CoA + 2-oxoglutarate + O2 = trans-6-hydroxyferuloyl-CoA + succinate + CO2
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trans-feruloyl-CoA + NADPH + H+ = dihydroferuloyl-CoA + NADP+
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feruloyl-CoA + tyramine = CoA + feruloyltyramine
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2 feruloyl-CoA + malonyl-CoA + H2O = 3 CoA + curcumin + 2 CO2
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feruloyl-CoA + malonyl-CoA = feruloylacetyl-CoA + CO2 + CoA
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(4-coumaroyl)acetyl-CoA + feruloyl-CoA + H2O = demethoxycurcumin + CO2 + CoA
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feruloyl-CoA + H2O = 3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA
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In Vivo Product in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
coniferaldehyde + CoA + NADP+ = feruloyl-CoA + NADPH + H+
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coniferaldehyde + CoA + NADP+ = feruloyl-CoA + NADPH + H+
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S-adenosyl-L-methionine + caffeoyl-CoA = S-adenosyl-L-homocysteine + feruloyl-CoA
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ferulic acid + CoASH + ATP = trans-feruloyl-CoA + products of ATP breakdown
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Substrate in Enzyme-catalyzed Reactions (79 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
trans-feruloyl-CoA + 2-oxoglutarate + O2 = trans-6-hydroxyferuloyl-CoA + succinate + CO2
show the reaction diagram
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trans-feruloyl-CoA + 2-oxoglutarate + O2 = trans-6-hydroxyferuloyl-CoA + succinate + CO2
show the reaction diagram
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feruloyl-CoA + 2 NADH + 2 oxidized ferredoxin iron-sulfur cluster = ? + 2 NAD+ + 2 reduced ferredoxin iron-sulfur cluster
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trans-feruloyl-CoA + NADPH + H+ = dihydroferuloyl-CoA + NADP+
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S-adenosyl-L-methionine + feruloyl-CoA = S-adenosyl-L-homocysteine + ?
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feruloyl-CoA + tartronic acid = CoA + feruloyltartronic acid
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feruloyl-CoA + isocitric acid = CoA + feruloylisocitric acid
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feruloyl-CoA + galactarate = CoA + O-feruloylgalactarate
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feruloyl-CoA + glucarate = CoA + feruloylglucarate
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feruloyl-CoA + glucarolactone = CoA + O-feruloylglucarolactone
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feruloyl-CoA + malonyl-CoA = rhapontigenin + CoA + CO2
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feruloyl-CoA + malonyl-CoA = feruloylacetyl-CoA + CO2 + CoA
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(4-coumaroyl)acetyl-CoA + feruloyl-CoA + H2O = demethoxycurcumin + CO2 + CoA
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feruloyl-CoA + malonyl-CoA = 3,4',5-trihydroxy-3'-methoxystilbene + CoA + CO2
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feruloyl-CoA + H2O = 3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (14 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
coniferaldehyde + CoA + NADP+ = feruloyl-CoA + NADPH + H+
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coniferaldehyde + CoA + NADP+ = feruloyl-CoA + NADPH + H+
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3,4-dihydroxyphenylpropanoyl-CoA + ferulate = 3,4-dihydroxyphenylpropanoate + feruloyl-CoA
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4-hydroxy-3-methoxy-phenyl-beta-hydroxypropionyl-CoA + H2O = vanillin + acetylCoA + feruloylCoA
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ferulic acid + CoASH + ATP = trans-feruloyl-CoA + products of ATP breakdown
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Inhibitor in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
competitive to caffeoyl-CoA, non-competitive to S-adenosyl-L-methionine
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (47 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.0042
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pH 50, 35°C
0.02
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pH 7.5, 37°C, recombinant enzyme

KM Value (91 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.05
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pH 7.2, 30°C
0.093
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pH 50, 35°C
0.163
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0.045
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Ki Value (3 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

References & Links

Links to other databases for feruloyl-CoA

ChEBI
PubChem
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PubChem