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Information on EC 4.1.2.4 - deoxyribose-phosphate aldolase
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4.1.2.4 deoxyribose-phosphate aldolaseSpecify your search results
Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
tgdpa, deoxyriboaldolase, 2-deoxyribose-5-phosphate aldolase, 2-deoxy-d-ribose-5-phosphate aldolase, deoxyribose-5-phosphate aldolase, deoxyribose-phosphate aldolase, deoxyribose 5-phosphate aldolase, 2-deoxy-d-ribose 5-phosphate aldolase, tk2104, tgdera, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
2-deoxy-D-ribose 5-phosphate aldolase
2-deoxy-D-ribose-5-phosphate aldolase
2-Deoxyribose-5-phosphate aldolase
aldolase, deoxyribo
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CGI-26
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d5RP aldolase
DeoC
Deoxyriboaldolase
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deoxyribose 5-phosphate aldolase
deoxyribose phosphate aldolase-like protein
Deoxyribose-5-phosphate aldolase
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deoxyribose-phosphate aldolase
DERA
DPA
DR aldolase
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Phosphodeoxyriboaldolase
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TgDERA
TgDPA
TtDERA
2-Deoxyribose-5-phosphate aldolase
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DERA
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde
mechanism
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2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde
Schiff base intermediate
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2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde
Schiff base intermediate
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2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde
forms a Schiff base intermediate with the substrate acetaldehyde
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2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde
complete equilibration of the methyl-group protons of the product, acetaldehyde, occurs before its release from the enzyme surface
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2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
aldol condensation
elimination
aldol condensation
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elimination
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of an aldehyde, C-C bond cleavage
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SYSTEMATIC NAME
IUBMB Comments
2-deoxy-D-ribose-5-phosphate acetaldehyde-lyase (D-glyceraldehyde-3-phosphate-forming)
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CAS REGISTRY NUMBER
COMMENTARY
9026-97-5
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(S)-4-chloro-3-hydroxybutanal + acetaldehyde
(3R,5S)-6-chloro-2,4,6-trideoxyhexapyranoside
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?
2-deoxy-D-ribose-5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
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?
3-azidopropanal + 2 acetaldehyde
(4R,6R)-6-(2-azidoethyl)-4-hydroxyoxan-2-one + 2 H+
-
-
-
?
3-azidopropionaldehyde + acetaldehyde
(4R,6R)-4-hydroxy-6-(2-triaz-2-en-1-ylethyl)tetrahydro-2H-pyran-2-one
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no activity with wild-type enzyme, mutant enzyme S238D gives 35% yield of the sequential aldol condensation product
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?
3-chloropropionaldehyde + acetaldehyde
(4R,6S)-6-(2-chloroethyl)-4-hydroxytetrahydro-2H-pyran-2-one
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wild type enzyme gives 25% yield of the sequential aldol condensation product, mutant enzyme S238D gives 43% yield of the sequential aldol condensation product
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?
3-Thioglyceraldehyde + acetaldehyde
2-Deoxy-5-thio-D-erythro-pentose
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?
5-O-(4'-methylumbelliferyl)-2-deoxy-D-ribose
3-O-(4'-methylumbelliferyl)-D-glyceraldehyde + acetaldehyde
acetaldehyde + acetaldehyde
?
enzyme directly immobilized through ionic exchange interactions on oxidized multiwalled carbon nanotubes catalyzes the reaction of acetaldehyde alone (self-condensation) or in the presence of chloro-acetaldehyde. The corresponding cyclic lactols are obtained in higher yield than with the native enzyme
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?
chloroacetaldehyde + acetaldehyde
?
enzyme directly immobilized through ionic exchange interactions on oxidized multiwalled carbon nanotubes catalyzes the reaction of acetaldehyde alone (self-condensation) or in the presence of chloro-acetaldehyde. The corresponding cyclic lactols are obtained in higher yield than with the native enzyme
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-
?
D-(R)-3-Azido-2-hydroxypropanal + acetaldehyde
5-Azido-(2R)-methyl-2,5-dideoxy-D-ribo-furanose
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-
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?
D-(R)-3-Azido-2-hydroxypropanal + acetone
6-Azido-1,3,5-trideoxy-D-erythro-hexulose
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-
-
?
D-(R)-3-Azido-2-hydroxypropanal + fluoroacetone
6-Azido-1-fluoro-1,3,5-trideoxy-D-erythro-hexulose
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-
-
?
D-2-deoxyribose
glyceraldehyde + acetaldehyde
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good substrate for the S238D mutant, weak substrate for the wild-type enzyme
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?
Glyceraldehyde phosphate + acetaldehyde
Hydroxyacetaldehyde + glyceraldehyde 3-phosphate
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-
-
-
?
Isobutyraldehyde + fluoroacetone
(S)-1-Fluoro-3-hydroxy-4-methylhexan-2-one
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?
(R)-3-Bromo-2-hydroxypropanal + acetaldehyde
5-Bromo-2-deoxyribose
-
-
-
?
(R)-3-Bromo-2-hydroxypropanal + acetaldehyde
5-Bromo-2-deoxyribose
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?
2-deoxy-D-ribose
D-glyceraldehyde + acetaldehyde
-
-
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r
2-deoxy-D-ribose
D-glyceraldehyde + acetaldehyde
JN665070
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?
2-deoxy-D-ribose 5-phosphate
?
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the induction of enzyme in anaerobic conditions may be considered as a reaction of the bacterial cell to the low energy yield of the sugar fermentation, leading to a more efficient chanelling of deoxyribose 5-phosphate into glycolysis
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?
2-deoxy-D-ribose 5-phosphate
?
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deoxyribonucleosides, but not ribonucleosides, induce the enzyme, thus allowing the sugar moiety of exogenous deoxyribonucleosides to be utilized as an energy source
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?
2-deoxy-D-ribose 5-phosphate
?
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enzyme of the intermediary carbohydrate metabolism
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?
2-deoxy-D-ribose 5-phosphate
?
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the enzyme may play a role in lowering the pools of deoxyribonucleotides in the late G2/M phase of the cell cycle
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?
2-deoxy-D-ribose 5-phosphate
?
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enzyme of the intermediary carbohydrate metabolism
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?
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
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-
-
?
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
-
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r
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
-
-
-
?
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
-
-
-
?
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
-
-
-
?
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
-
-
-
-
?
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
-
-
-
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?
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
-
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?
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
-
-
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?
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
-
-
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?
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
-
-
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?
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
-
-
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?
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
-
-
-
?
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
-
-
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?
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
-
-
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?
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
-
-
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?
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
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-
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?
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
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-
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?
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
-
-
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?
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
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-
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?
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
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-
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?
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
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-
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?
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
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-
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?
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
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-
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?
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
-
-
-
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?
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
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r
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
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-
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r
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
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-
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?
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
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-
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r
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
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-
-
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?
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
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-
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?
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
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-
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?
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
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-
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?
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
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-
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r
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
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-
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r
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
-
-
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?
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
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-
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?
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
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-
-
?
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
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-
-
?
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
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-
-
-
?
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
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-
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?
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
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-
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r
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
-
-
r
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
-
-
-
r
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
-
-
r
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
-
-
-
?
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
-
-
-
?
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
-
-
-
?
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
-
-
-
?
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
-
-
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?
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
-
-
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r
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
-
-
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r
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
-
-
-
-
?
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
-
-
-
?
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
-
-
-
?
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
-
-
-
?
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
-
-
-
?
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
-
-
-
-
?
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
JN665070
-
-
-
?
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
JN665070
-
-
-
?
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
-
-
-
?
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
-
-
-
?
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
-
-
-
?
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
-
-
-
?
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
-
-
-
?
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
-
-
-
?
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
-
specific for 2-deoxy-D-ribose 5-phosphate
-
?
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
-
-
-
-
?
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
-
-
r
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
-
-
r
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
-
-
-
?
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
-
-
-
?
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
-
-
-
?
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
-
-
-
?
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
presence of a novel phosphopentomutase and a 2-deoxyribose 5-phosphate aldolase reveals a metabolic link between pentoses and central carbon metabolism. Alternative route for pentose biosynthesis trough the function of the novel phosphopentomutase and a 2-deoxyribose 5-phosphate aldolase
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?
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
-
-
-
-
?
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
-
-
-
-
?
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
Thermus thermophilus HB8 / ATCC 27634 / DSM 579
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?
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
-
-
-
-
?
2-deoxy-D-ribose 5-phosphate
D-glyceraldehyde 3-phosphate + acetaldehyde
-
-
-
?
2-hydroxy-3-butenal + acetaldehyde
2,5,6-trideoxy-D-erythro-5-hexenose
-
-
-
?
2-hydroxy-3-butenal + acetaldehyde
2,5,6-trideoxy-D-erythro-5-hexenose
-
-
-
?
3-Chloro-2-hydroxypropanal + propionaldehyde
5-Chloro-2-methylribose
-
-
-
?
3-Chloro-2-hydroxypropanal + propionaldehyde
5-Chloro-2-methylribose
-
-
-
?
5-O-(4'-methylumbelliferyl)-2-deoxy-D-ribose
3-O-(4'-methylumbelliferyl)-D-glyceraldehyde + acetaldehyde
-
higher activity with 5-O-(4'-methylumbelliferyl)-2-deoxy-L-ribose than with 5-O-(4'-methylumbelliferyl)-2-deoxy-D-ribose
-
-
?
5-O-(4'-methylumbelliferyl)-2-deoxy-D-ribose
3-O-(4'-methylumbelliferyl)-D-glyceraldehyde + acetaldehyde
-
-
-
-
?
5-O-(4'-methylumbelliferyl)-2-deoxy-D-ribose
3-O-(4'-methylumbelliferyl)-D-glyceraldehyde + acetaldehyde
-
low activity
-
-
?
5-O-(4'-methylumbelliferyl)-2-deoxy-D-ribose
3-O-(4'-methylumbelliferyl)-D-glyceraldehyde + acetaldehyde
-
-
-
-
?
5-O-(4'-methylumbelliferyl)-2-deoxy-D-ribose
3-O-(4'-methylumbelliferyl)-D-glyceraldehyde + acetaldehyde
-
-
-
-
?
5-O-(4'-methylumbelliferyl)-2-deoxy-D-ribose
3-O-(4'-methylumbelliferyl)-D-glyceraldehyde + acetaldehyde
-
low activity
-
-
?
5-O-(4'-methylumbelliferyl)-2-deoxy-D-xylose
?
-
low activity
-
-
?
5-O-(4'-methylumbelliferyl)-2-deoxy-L-ribose
?
-
higher activity with 5-O-(4'-methylumbelliferyl)-2-deoxy-L-ribose than with 5-O-(4'-methylumbelliferyl)-2-deoxy-D-ribose
-
-
?
D-glyceraldehyde 3-phosphate + acetaldehyde
2-deoxy-D-ribose 5-phosphate
-
-
-
-
?
D-glyceraldehyde 3-phosphate + acetaldehyde
2-deoxy-D-ribose 5-phosphate
-
-
-
r
D-glyceraldehyde 3-phosphate + acetaldehyde
2-deoxy-D-ribose 5-phosphate
-
-
-
-
?
D-glyceraldehyde 3-phosphate + acetaldehyde
2-deoxy-D-ribose 5-phosphate
-
-
-
-
?
D-glyceraldehyde 3-phosphate + acetaldehyde
2-deoxy-D-ribose 5-phosphate
2-deoxy-D-ribose 5-phosphate-producing activity is highest in the presence of 300 mM acetaldehyde
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-
r
D-glyceraldehyde 3-phosphate + acetaldehyde
2-deoxy-D-ribose 5-phosphate
2-deoxy-D-ribose 5-phosphate-producing activity is highest in the presence of 300 mM acetaldehyde
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-
r
D-glyceraldehyde 3-phosphate + acetaldehyde
2-deoxy-D-ribose 5-phosphate
-
-
-
?
D-glyceraldehyde 3-phosphate + acetaldehyde
2-deoxy-D-ribose 5-phosphate
-
-
-
-
?
D-glyceraldehyde 3-phosphate + acetaldehyde
2-deoxy-D-ribose 5-phosphate
-
-
-
r
D-glyceraldehyde 3-phosphate + acetaldehyde
2-deoxy-D-ribose 5-phosphate
-
-
-
r
D-glyceraldehyde 3-phosphate + acetaldehyde
2-deoxy-D-ribose 5-phosphate
-
-
-
?
D-glyceraldehyde 3-phosphate + acetaldehyde
2-deoxy-D-ribose 5-phosphate
-
-
-
?
D-glyceraldehyde 3-phosphate + acetaldehyde
2-deoxy-D-ribose 5-phosphate
-
-
-
?
D-glyceraldehyde 3-phosphate + acetaldehyde
2-deoxy-D-ribose 5-phosphate
-
-
-
?