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Literature summary for 4.1.2.4 extracted from

  • Salleron, L.; Magistrelli, G.; Mary, C.; Fischer, N.; Bairoch, A.; Lane, L.
    DERA is the human deoxyribose phosphate aldolase and is involved in stress response (2014), Biochim. Biophys. Acta, 1843, 2913-2925 .
    View publication on PubMed
Search for more literature for 4.1.2.4

Cloned(Commentary)

Cloned (Comment) Organism
DERA-6xHis and mutants (K218A, K254A and K218A/K254A) are overexpressed in HeLa cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
down cells in which deoxyribose-phosphate aldolase expression is down-regulated using short hairpin RNA form fewer stress granules and are more prone to apoptosis after clotrimazole stress, suggesting the importance of deoxyribose-phosphate aldolase for stress granule formation Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
stress granule
-
 Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9Y315
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Caco-2 cell high activity Homo sapiens
-
colon mainly expressed in lung, liver and colon Homo sapiens
-
Hep-G2 cell moderate activity Homo sapiens
-
Huh-7 cell among human cell lines, the highest deoxyribose-phosphate aldolase mRNA level and deoxyribose phosphate aldolase activity are observed in liver-derived Huh-7 cells Homo sapiens
-
JURKAT cell moderate activity Homo sapiens
-
liver mainly expressed in lung, liver and colon Homo sapiens
-
lung mainly expressed in lung, liver and colon Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-deoxy-D-ribose 5-phosphate
-
 Homo sapiens D-glyceraldehyde 3-phosphate + acetaldehyde
-
 ?

Synonyms

Synonyms Comment Organism
DERA
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.8
-
 assay at Homo sapiens

General Information

General Information Comment Organism
metabolism the expression of deoxyribose-phosphate aldolase enables cells in which mitochondrial ATP production is abolished to make use of extracellular deoxyinosine to maintain ATP levels. This pathway may allow cells with high deoxyribose-phosphate aldolase activity, such as liver cells, to minimize or delay stress-induced damage by producing energy through deoxynucleoside degradation Homo sapiens
physiological function the enzyme is involved in stress response. The enzyme interacts with the stress granule component YBX1 and is recruited to stress granules after oxidative or mitochondrial stress Homo sapiens