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Literature summary for 4.1.2.4 extracted from
- Deoxyribose 5-phosphate aldolase. II. Purification and properties of the rat liver enzyme (1967), J. Biol. Chem., 242, 155-159.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| adipate | activates | Rattus norvegicus |  |
| cis-aconitate | activates | Rattus norvegicus | |
| citrate | no activity in absence of the activator | Rattus norvegicus | |
| DL-isocitrate | activates | Rattus norvegicus | |
| fumarate | activates | Rattus norvegicus | |
| Fumarate monomethyl ester | activates | Rattus norvegicus | |
| Glutarate | activates | Rattus norvegicus | |
| malate | activates | Rattus norvegicus | |
| succinate | activates | Rattus norvegicus | |
| tricarballylate | activates | Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.17 | - |
2-deoxy-D-ribose 5-phosphate | - |
Rattus norvegicus | |
| 0.2 | - |
D-glyceraldehyde 3-phosphate | - |
Rattus norvegicus | |
| 0.267 | - |
acetaldehyde | - |
Rattus norvegicus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 253000 | - |
monomeric form, sucrose density gradient centrifugation | Rattus norvegicus |
| 535000 | - |
dimeric form, sucrose density gradient centrifugation | Rattus norvegicus |
| 700000 | - |
trimeric form, sucrose density gradient centrifugation | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-Glyceraldehyde 3-phosphate + acetaldehyde | Rattus norvegicus | the enzyme may have an important role as a source of 2-deoxyribose 5-phosphate for deoxynucleotide synthesis in rat liver | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 1.775 | - |
- |
Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-deoxy-D-ribose 5-phosphate | - |
Rattus norvegicus | D-glyceraldehyde 3-phosphate + acetaldehyde | - |
? | |
| D-glyceraldehyde 3-phosphate + acetaldehyde | - |
Rattus norvegicus | 2-deoxy-D-ribose 5-phosphate | - |
? | |
| D-Glyceraldehyde 3-phosphate + acetaldehyde | the enzyme may have an important role as a source of 2-deoxyribose 5-phosphate for deoxynucleotide synthesis in rat liver | Rattus norvegicus | ? | - |
? | |
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