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Information on EC - phosphonopyruvate decarboxylase

for references in articles please use BRENDA:EC4.1.1.82
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EC Tree
     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.1 Carboxy-lyases
       phosphonopyruvate decarboxylase
IUBMB Comments
The enzyme catalyses a step in the biosynthetic pathway of 2-aminoethylphosphonate, a component of the capsular polysaccharide complex of Bacteroides fragilis. Requires thiamine diphosphate and Mg2+ as cofactors. The enzyme is activated by the divalent cations Mg2+, Ca2+ and Mn2+. Pyruvate and sulfopyruvate can also act as substrates, but more slowly. This enzyme drives the reaction catalysed by EC, phosphoenolpyruvate mutase, in the thermodynamically unfavourable direction of 3-phosphonopyruvate formation . It is the initial step in all of the major biosynthetic pathways of phosphonate natural products .
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Word Map
The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota
phosphonopyruvate decarboxylase, pnpy decarboxylase, ppyr decarboxylase, more
3-phosphonopyruvate = 2-phosphonoacetaldehyde + CO2
show the reaction diagram
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