show all | hide all No of entries

Information on EC 4.1.1.82 - phosphonopyruvate decarboxylase

for references in articles please use BRENDA:EC4.1.1.82
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.1 Carboxy-lyases
                4.1.1.82 phosphonopyruvate decarboxylase
IUBMB Comments
The enzyme catalyses a step in the biosynthetic pathway of 2-aminoethylphosphonate, a component of the capsular polysaccharide complex of Bacteroides fragilis. Requires thiamine diphosphate and Mg2+ as cofactors. The enzyme is activated by the divalent cations Mg2+, Ca2+ and Mn2+. Pyruvate and sulfopyruvate can also act as substrates, but more slowly. This enzyme drives the reaction catalysed by EC 5.4.2.9, phosphoenolpyruvate mutase, in the thermodynamically unfavourable direction of 3-phosphonopyruvate formation . It is the initial step in all of the major biosynthetic pathways of phosphonate natural products .
Specify your search results
Select one or more organisms in this record:
Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
pnpy decarboxylase, ppyr decarboxylase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
3-phosphonopyruvate = 2-phosphonoacetaldehyde + CO2
show the reaction diagram
-
-
-
-
Select items on the left to see more content.