Literature summary for 4.1.1.82 extracted from

Pallitsch, K.; Rogers, M.P.; Andrews, F.H.; Hammerschmidt, F.; McLeish, M.J.
Phosphonodifluoropyruvate is a mechanism-based inhibitor of phosphonopyruvate decarboxylase from Bacteroides fragilis (2017), Bioorg. Med. Chem., 25, 4368-4374 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
phosphonodifluoropyruvate	mechanism-based inhibitor, irreversibly inactivates the enzyme, accompanied by release of fluoride ion	Bacteroides fragilis

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.0029	-	3-phosphonopyruvate	pH 7.0, 30°C	Bacteroides fragilis

Organism

Organism	UniProt	Comment	Textmining
Bacteroides fragilis	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3-phosphonopyruvate	-	Bacteroides fragilis	2-phosphonoacetaldehyde + CO2	-	?

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
10.1	-	3-phosphonopyruvate	pH 7.0, 30°C	Bacteroides fragilis

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Release 2023.1 (January 2023)