Information on EC 3.6.1.74 - mRNA 5'-phosphatase

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EC Tree
     3 Hydrolases
         3.6 Acting on acid anhydrides
             3.6.1 In phosphorus-containing anhydrides
                3.6.1.74 mRNA 5'-phosphatase
IUBMB Comments
The enzyme, found in eukaryotes and some plus strand RNA viruses (e.g. alphavirus), is involved in mRNA capping. Unlike the eukaryotic enzyme, the viral enzyme requires a purine in the first position of the mRNA. The human enzyme is a multi domain protein that also has the activity of EC 2.7.7.50, mRNA guanylyltransferase.
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Word Map
The enzyme appears in viruses and cellular organisms
Reaction Schemes
Synonyms
5'-polynucleotidase, CaCET1, CaCet1p, capping enzyme beta subunit, capping enzyme RNA 5'-triphosphatase-like 1, CES5, CET1, Cet1 RNA triphosphatase, Ctl1, hCAP1a, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a 5'-triphospho-[mRNA] + H2O = a 5'-diphospho-[mRNA] + phosphate
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PATHWAY SOURCE
PATHWAYS
MetaCyc
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