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Literature summary for 3.6.1.74 extracted from

  • Pillutla, R.; Shimamoto, A.; Furuichi, Y.; Shatkin, A.
    Human mRNA capping enzyme (RNGTT) and cap methyltransferase (RNMT) map to 6q16 and 18p11.22-p11.23, respectively (1998), Genomics, 54, 351-353 .
No PubMed abstract available
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Cloned(Commentary)

Cloned (Comment) Organism
gene RNGTT, DNA and amino acid sequence deterination and analysis, genetic organization, human mRNA capping enzyme maps to chromosome 6q16 between STS markers AFMB298ZG9 and AFM185XD10 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
a 5'-triphospho-[mRNA] + H2O Homo sapiens
-
 a 5'-diphospho-[mRNA] + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O60942
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
a 5'-triphospho-[mRNA] + H2O
-
 Homo sapiens a 5'-diphospho-[mRNA] + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
mRNA-capping enzyme
-
 Homo sapiens
RNGTT
-
 Homo sapiens

General Information

General Information Comment Organism
evolution metazoans including humans contain a separate cap methyltransferase (RNA guanine-7-methyltransferase, RNMT), but the RNA 5'-triphosphatase and guanylyltransferase activities are contained as N- and C-terminal domains in a bifunctional capping enzyme (RNGTT) encoded by a single gene Homo sapiens
physiological function the capping enzyme selectively binds to the phosphorylated, elongating form of RNA polymerase II (polII) for specific capping of pol II transcripts. Caps are formed on nascent pre-mRNAs by the sequential action of RNA 5'-triphosphatase, which removes the gamma-phosphate of the initiating nucleotide, RNA guanylyltransferase, which transfers GMP from GTP to the resulting diphosphate end, and RNA (guanine-7) methyltransferase, which methylates the guanine N7 position of the newly formed GpppN termini Homo sapiens