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ephrin receptor B4 + H2O
?
-
-
-
?
proteins + H2O
peptides
-
-
?
ADAM10 + H2O
?
-
shedding of the ectodomain of ADAM10
-
-
?
amyloid precursor protein + H2O
90-100 kDa non-amyloid N-terminal protein fragment
-
alpha-secretase activity
-
?
amyloid precursor protein + H2O
?
-
-
-
-
?
beta-casein + H2O
?
-
-
-
-
?
EVHHQKLVFFAE + H2O
EVHH + QKLVFFAE
-
peptides derived from beta-amyloid precursor protein, comprises the predicted cleavage site
-
?
Fibronectin + H2O
?
-
-
-
-
?
Gelatin + H2O
?
-
-
-
-
?
heparin-binding EGF-like growth factor + H2O
heparin-binding EGF-like growth factor fragment
-
cooperative action with bound protein kinase C, membrane-anchored substrate, ectodomain shedding
soluble product
?
insulin B chain + H2O
3 peptides
-
cleavage sites are Tyr16-Leu17 and Tyr26-Thr27
-
?
insulin B chain + H2O
?
-
-
-
-
?
pro-heparin-binding EGF-like growth factor + H2O
?
SMAPGAVHLPQP + H2O
SMAPGAVH + LPQP
-
peptides derived from P75 TNF-receptor, comprises the predicted cleavage site
-
?
SPLAQAVRSSSR + H2O
SPLA + QAVRSSSR
-
peptides derived from TNF-alpha, comprises the predicted cleavage site
-
?
SPLAQAVRSSSR + H2O
SPLAQAVRS + SSR
-
peptides derived from TNF-alpha, comprises the predicted cleavage site
-
?
additional information
?
-
pro-heparin-binding EGF-like growth factor + H2O
?
-
-
-
-
?
pro-heparin-binding EGF-like growth factor + H2O
?
-
cooperative action with bound protein kinase C, membrane-anchored substrate, ectodomain shedding
-
?
proteins + H2O
peptides
-
-
-
?
proteins + H2O
peptides
-
-
-
?
proteins + H2O
peptides
-
-
-
?
proteins + H2O
peptides
-
-
-
?
additional information
?
-
-
interaction with endophilin I and SH3PX1, a SH3 domain- and phox homolog domain-containing protein, which may have a regulatory role by inhibiting the processing of the enzyme
-
?
additional information
?
-
-
regulation of metalloprotease desintegrins via a cysteine-switch mechanism
-
?
additional information
?
-
-
enzyme can cleave and release epidermal growth factor and FGFR2iiib from cells
-
-
?
additional information
?
-
-
enzyme is a polyvalent ligand, through its disintegrin domain, for multiple renal integrins of the beta1 class
-
-
?
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additional information
-
construction of several deletion mutants lacking amino acids of the cytoplasmic region by site-directed mutagenesis
additional information
-
site-directed mutagenesis of the furin cleavage site and of the cysteine-switch region results in highly reduced precursor processing, construction of a deletion mutant resulting in a soluble enzyme form
additional information
-
enzyme overexpression in A-549 and EBC-1 cells results in increased invasive capacity in response to nerve growth factor, increased adhesion to brain tissue, and increased expression of integrin alpha3 and beta1 subunits. Administration of enzyme overexpressing A-549 cells to mice results in micrometastatic foci in brain and multiple metastatic colonies in the lungs
additional information
-
enzyme-deficient W10 animals, tumors are well-differentiated, whereas enzyme wild-type W10 animals show predominantly poorly differentiated, and in some cases significantly larger, tumors
additional information
-
expression of intact enzyme and a series of deletion constructs sequentially lacking the metalloprotease domain and the disintegrin domain assembled as chimeras with a C-terminal GFP tag. Stable expression of constructs on the surface of HEK-293 cells significantly decreases adhesion to types I and IV collagen, vitronectin and laminin, but has little effect on adhesion to fibronectin
additional information
-
overexpression of enzyme enhances growth factor-mediated induction of endocytosis and dynamic recycling of E-cadherin in the human colon cancer cell line HT-29. Enzyme constitutively interacts with E-cadherin, the two proteins co-localize at the plasma membrane
additional information
-
reduced photoreceptor responses occur in Adam9 knockout mice. In 12-month-old knockout mice, photoreceptors appear normal, but the apical processes of the retinal pigment epithelium cells are disorganized and contact between photoreceptor outer segments, POSs, and the RPE apical surface is compromised. In 20-month-old mice, there is clear evidence of progressive retinal degeneration with disorganized POS and thinning of the outer nuclear layer in addition to the anomaly at the POS-RPE junction. RPE basal deposits and macrophages are also apparent in older mice, phenotypes, overview
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Boeckmann, B.; Bairoch, A.; Apweiler, R.; Blatter, M.C.; Estreicher, A.; Gasteiger, E.; Martin M.J.; Michoud, K.; O'Donovan, C.; Phan, I.; Pilbout, S.; Schneider, M.
The SWISS-PROT protein knowledgebase and its supplement TrEMBL
Nucleic Acids Res.
31
365-370
2003
Homo sapiens (Q13443), Mus musculus (Q61072)
brenda
Koike, H.; Tomioka, S.; Sorimachi, H.; Saido, T.C.; Maruyama, K.; Okuyama, A.; Fujisawa-Sehara, A.; Ohno, S.; Suzuki, K.; Ishiura, S.
Membrane-anchored metalloprotease MDC9 has an alpha-secretase activity responsible for processing the amyloid precursor protein
Biochem. J.
343
371-375
1999
Mus musculus
brenda
Izumi, Y.; Hirata, M.; Hasuwa, H.; Iwamoto, R.; Umata, T.; Miyado, K.; Tamai, Y.; Kurisaki, T.; Sehara-Fujisawa, A.; Ohno, S.; Mekada, E.
A metalloprotease-disintegrin, MDC9/meltrin-gamma/ADAM9 and PKCdelta are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor
EMBO J.
17
7260-7272
1998
Mus musculus
brenda
Howard, L.; Nelson, K.K.; Maciewicz, R.A.; Blobel, C.P.
Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1
J. Biol. Chem.
274
31693-31699
1999
Homo sapiens, Mus musculus
brenda
Roghani, M.; Becherer, J.D.; Moss, M.L.; Atherton, R.E.; Erdjument-Bromage, H.; Arribas, J.; Blackburn, R.K.; Weskamp, G.; Tempst, P.; Blobel, C.P.
Metalloprotease-disintegrin MDC9: intracellular maturation and catalytic activity
J. Biol. Chem.
274
3531-3540
1999
Mus musculus
brenda
Mahimkar, R.M.; Visaya, O.; Pollock, A.S.; Lovett, D.H.
The disintegrin domain of ADAM9: a ligand for multiple b1 renal integrins
Biochem. J.
385
461-468
2005
Mus musculus
brenda
Shintani, Y.; Higashiyama, S.; Ohta, M.; Hirabayashi, H.; Yamamoto, S.; Yoshimasu, T.; Matsuda, H.; Matsuura, N.
Overexpression of ADAM9 in non-small cell lung cancer correlates with brain metastasis
Cancer Res.
64
4190-4196
2004
Homo sapiens, Mus musculus
brenda
Peduto, L.; Reuter, V.E.; Shaffer, D.R.; Scher, H.I.; Blobel, C.P.
Critical function for ADAM9 in mouse prostate cancer
Cancer Res.
65
9312-9319
2005
Mus musculus
brenda
Asayesh, A.; Alanentalo, T.; Khoo, N.K.; Ahlgren, U.
Developmental expression of metalloproteases ADAM 9, 10, and 17 becomes restricted to divergent pancreatic compartments
Dev. Dyn.
232
1105-1114
2005
Mus musculus
brenda
Hirao, T.; Nanba, D.; Tanaka, M.; Ishiguro, H.; Kinugasa, Y.; Doki, Y.; Yano, M.; Matsuura, N.; Monden, M.; Higashiyama, S.
Overexpression of ADAM9 enhances growth factor-mediated recycling of E-cadherin in human colon cancer cell line HT29 cells
Exp. Cell Res.
312
331-339
2006
Mus musculus
brenda
Deuss, M.; Reiss, K.; Hartmann, D.
Part-time alpha-secretases: the functional biology of ADAM 9, 10 and 17
Curr. Alzheimer Res.
5
187-201
2008
Mus musculus
brenda
Parry, D.A.; Toomes, C.; Bida, L.; Danciger, M.; Towns, K.V.; McKibbin, M.; Jacobson, S.G.; Logan, C.V.; Ali, M.; Bond, J.; Chance, R.; Swendeman, S.; Daniele, L.L.; Springell, K.; Adams, M.; Johnson, C.A.; Booth, A.P.; Jafri, H.; Rashid, Y.; Banin, E.; Strom, T.M.; Farber, D.B.; Sharon, D.; Blobel, C.P.; Pugh, E.
Loss of the metalloprotease ADAM9 leads to cone-rod dystrophy in humans and retinal degeneration in mice
Am. J. Hum. Genet.
84
683-691
2009
Homo sapiens, Mus musculus
brenda
Abety, A.N.; Fox, J.W.; Schoenefuss, A.; Zamek, J.; Landsberg, J.; Krieg, T.; Blobel, C.; Mauch, C.; Zigrino, P.
Stromal fibroblast-specific expression of ADAM-9 modulates proliferation and apoptosis in melanoma cells in vitro and in vivo
J. Invest. Dermatol.
132
2451-2458
2012
Mus musculus (Q61072), Mus musculus
brenda
Wang, X.; Polverino, F.; Rojas-Quintero, J.; Zhang, D.; Sánchez, J.; Yambayev, I.; Lindqvist, E.; Virtala, R.; Djukanovic, R.; Davies, D.; Wilson, S.; ODonnell, R.; Cunoosamy, D.; Hazon, P.; Higham, A.; Singh, D.; Olsson, H.; Owen, C.
A disintegrin and metalloproteinase domain-9 A novel proteinase culprit with multifarious contributions to chronic obstructive pulmonary disease
Am. J. Respir. Crit. Care Med.
198
1500-1518
2018
Mus musculus, Homo sapiens (Q13443)
-
brenda
English, W.; Siviter, R.; Hansen, M.; Murphy, G.
ADAM9 is present at endothelial cell - cell junctions and regulates monocyte - endothelial transmigration
Biochem. Biophys. Res. Commun.
493
1057-1062
2017
Mus musculus (Q61072)
brenda
Maretzky, T.; Swendeman, S.; Mogollon, E.; Weskamp, G.; Sahin, U.; Reiss, K.; Blobel, C.
Characterization of the catalytic properties of the membrane-anchored metalloproteinase ADAM9 in cell-based assays
Biochem. J.
474
1469-1479
2017
Mus musculus (Q61072)
brenda