Literature summary for 3.4.24.B9 extracted from

Abety, A.N.; Fox, J.W.; Schoenefuss, A.; Zamek, J.; Landsberg, J.; Krieg, T.; Blobel, C.; Mauch, C.; Zigrino, P.
Stromal fibroblast-specific expression of ADAM-9 modulates proliferation and apoptosis in melanoma cells in vitro and in vivo (2012), J. Invest. Dermatol., 132, 2451-2458.

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Application

Application	Comment	Organism
medicine	injection of murine melanoma cells into the flank of ADAM-9-/- animals resultsin the development of significantly larger tumors than in wild-type animals as a result of increased proliferation and decreased apoptosis of melanoma cells	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q61072	-	-

General Information

General Information	Comment	Organism
physiological function	coculture of melanoma cells in the presence of ADAM-9-/- fibroblasts leads to increased melanoma cell proliferation and reduced apoptosis as compared with control cocultures. TIMP-1 and sTNFRI are the two relevant factors expressed in increased amounts in culture supernatants from ADAM-9-/- fibroblasts. TIMP-1 is associated with induced melanoma cell proliferation, whereas soluble TNFR1 mediates the reduced cellular apoptosis in vitro. In vivo, injection of murine melanoma cells into the flank of ADAM-9-/- animals results in the development of significantly larger tumors than in wild-type animals as a result of increased proliferation and decreased apoptosis of melanoma cells	Mus musculus

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Release 2023.1 (January 2023)