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Literature summary for 3.4.24.B9 extracted from

  • Izumi, Y.; Hirata, M.; Hasuwa, H.; Iwamoto, R.; Umata, T.; Miyado, K.; Tamai, Y.; Kurisaki, T.; Sehara-Fujisawa, A.; Ohno, S.; Mekada, E.
    A metalloprotease-disintegrin, MDC9/meltrin-gamma/ADAM9 and PKCdelta are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor (1998), EMBO J., 17, 7260-7272.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.B9

Activating Compound

Activating Compound Comment Organism Structure
Protein kinase C binds to the enzyme at its cytoplasmic part and cooperates in cleavage of EGF-like growth factor Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
expression of GST-linked cytoplasmic region in Escherichia coli, coeexpression of the enzyme and protein kinase C in COS-7 cells, overexpression of wild-type and deletion mutants in Vero-H cells Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information construction of several deletion mutants lacking amino acids of the cytoplasmic region by site-directed mutagenesis Mus musculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
12000
-
 x * 84000, processed enzyme, x * 12000, enzyme proform, SDS-PAGE Mus musculus
84000
-
 x * 84000, processed enzyme, x * 12000, enzyme proform, SDS-PAGE Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
heparin-binding EGF-like growth factor + H2O Mus musculus cooperative action with bound protein kinase C, membrane-anchored substrate, ectodomain shedding heparin-binding EGF-like growth factor fragment soluble product ?
pro-heparin-binding EGF-like growth factor + H2O Mus musculus cooperative action with bound protein kinase C, membrane-anchored substrate, ectodomain shedding ?
-
 ?
proteins + H2O Mus musculus
-
 peptides
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification
-
 Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
heparin-binding EGF-like growth factor + H2O cooperative action with bound protein kinase C, membrane-anchored substrate, ectodomain shedding Mus musculus heparin-binding EGF-like growth factor fragment soluble product ?
pro-heparin-binding EGF-like growth factor + H2O cooperative action with bound protein kinase C, membrane-anchored substrate, ectodomain shedding Mus musculus ?
-
 ?
proteins + H2O
-
 Mus musculus peptides
-
 ?

Subunits

Subunits Comment Organism
? x * 84000, processed enzyme, x * 12000, enzyme proform, SDS-PAGE Mus musculus

Synonyms

Synonyms Comment Organism
ADAM9
-
 Mus musculus
M12.209 Merops-ID Mus musculus
MDC9
-
 Mus musculus
MDC9/meltrin-gamma/ADAM9
-
 Mus musculus
meltrin-gamma
-
 Mus musculus