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Literature summary for 3.4.24.B9 extracted from

  • Howard, L.; Nelson, K.K.; Maciewicz, R.A.; Blobel, C.P.
    Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1 (1999), J. Biol. Chem., 274, 31693-31699.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression of FLAG-tagged enzyme in COS-7 cells Mus musculus
expression of GST-fusion cytoplasmic enzyme domain in a two-hybrid system in Saccharomyces cerevisiae strain HF7c Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus interaction with endophilin I and SH3PX1, a SH3 domain- and phox homolog domain-containing protein, which may have a regulatory role by inhibiting the processing of the enzyme ?
-
?
additional information Homo sapiens interaction with endophilin I and SH3PX1, a SH3 domain- and phox homolog domain-containing protein, which may have a regulatory role by inhibiting the processing of the enzyme ?
-
?
proteins + H2O Mus musculus
-
peptides
-
?
proteins + H2O Homo sapiens
-
peptides
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification cleavage of prodomain by furin, interaction with endophilin I and SH3PX1, a SH3 domain- and phox homolog domain-containing protein, which may have a regulatory role by inhibiting the processing of the enzyme Mus musculus
proteolytic modification cleavage of prodomain by furin, interaction with endophilin I and SH3PX1, a SH3 domain- and phox homolog domain-containing protein, which may have a regulatory role by inhibiting the processing of the enzyme Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information interaction with endophilin I and SH3PX1, a SH3 domain- and phox homolog domain-containing protein, which may have a regulatory role by inhibiting the processing of the enzyme Mus musculus ?
-
?
additional information interaction with endophilin I and SH3PX1, a SH3 domain- and phox homolog domain-containing protein, which may have a regulatory role by inhibiting the processing of the enzyme Homo sapiens ?
-
?
proteins + H2O
-
Mus musculus peptides
-
?
proteins + H2O
-
Homo sapiens peptides
-
?

Synonyms

Synonyms Comment Organism
M12.209 Merops-ID Mus musculus
M12.209 Merops-ID Homo sapiens
MDC9
-
Mus musculus
MDC9
-
Homo sapiens