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Information on EC 3.2.1.74 - glucan 1,4-beta-glucosidase
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EC Tree
3.2.1.74 glucan 1,4-beta-glucosidaseIUBMB Comments
Acts on 1,4-beta-D-glucans and related oligosaccharides. Cellobiose is hydrolysed, but very slowly.
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Word Map
- 3.2.1.74
- endoglucanase
- cellulases
- cellobiose
- trichoderma
-
cellulolytic
- reesei
- xylanase
- avicel
-
lignocellulosic
-
cellulosic
-
saccharification
- cmcase
-
microcrystalline
- straw
-
cellulose-binding
- xylan
-
3.2.1.21
- cellulosome
- fusca
- thermocellum
- cellotetraose
- beta-d-glucoside
- thermobifida
- cellulomonas
- endocellulase
- bagasse
-
cellulose-degrading
- cellopentaose
- hypocrea
- jecorina
-
acid-swollen
- cellodextrins
- fibrobacter
- endo-beta-1,4-glucanase
- endoxylanase
- avicelase
- myrosinase
-
fpase
- carboxymethylcellulase
- neocallimastix
- endo-1,4-beta-glucanase
-
lignocellulolytic
- cellooligosaccharides
- flavefaciens
-
dockerins
- humicola
- biofuel production
- biotechnology
-
cellulase-producing
- ruminicola
- insolens
- analysis
- energy production
- cellulovorans
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
cellobiohydrolase, exoglucanase, cellobiase, glucohydrolase, carboxymethyl cellulase, cel9a, exocellulase, cel48a, endo-1,4-beta-d-glucanase, beta-1,4-glucosidase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
1,4-beta-D-glucan glucanohydrolase
b-glucan glucohydrolase
beta-(1-4)-glucanase
beta-1,4-beta-glucanase
-
-
-
-
beta-1,4-glucosidase
beta-glucosidase
beta-glucosidase/xylosidase
bifunctional, belongs to to the glycoside hydrolase 3 familiy, GH3
Bgl
BglA
cellobiase
Cellulase
endo-1,4-beta-D-glucanase
endo/exocellulase
exo-1,4-beta-glucanase
exo-1,4-beta-glucosidase
-
-
-
-
exo-beta-1,4-glucanase
exo-beta-1,4-glucosidase
-
-
-
-
exocellulase
family-1 glycosyl hydrolase
FiG
glucan 1,4-beta-glucosidase
NA23_08975
Rubg3A
gene name, together with Rubg3B, beta-glucosidase/xylosidase activity, EC 3.2.1.37 and 3.2.1.74
Rubg3B
gene name, together with Rubg3A, beta-glucosidase/xylosidase activity, EC 3.2.1.37 and 3.2.1.74
Xyn10E
b-glucan glucohydrolase
extracellular non-cellulosomal beta-glucan glucohydrolase
b-glucan glucohydrolase
extracellular non-cellulosomal beta-glucan glucohydrolase
-
beta-1,4-glucosidase
Vibrio cholerae serotype O1 E1 Tor N16961
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-
-
beta-glucosidase
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-
-
-
beta-glucosidase
Vibrio cholerae serotype O1 E1 Tor N16961
-
-
-
BglA
Vibrio cholerae serotype O1 E1 Tor N16961
-
-
-
cellobiase
Vibrio cholerae serotype O1 E1 Tor N16961
-
-
-
exo-1,4-beta-glucanase
-
-
-
-
exo-beta-1,4-glucanase
-
-
-
-
exocellulase
-
-
-
-
Xyn10E
-
bifunctional recombinant enzyme with xylanase and beta-glucanase activities
Xyn10E
-
bifunctional recombinant enzyme with xylanase and beta-glucanase activities
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
(Glcbeta(1-4))r + H2O = (Glcbeta(1-4))r-1 + beta-D-glucopyranose
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of O-glycosyl bond
hydrolysis of O-glycosyl bond
-
-
-
-
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SYSTEMATIC NAME
IUBMB Comments
4-beta-D-glucan glucohydrolase
Acts on 1,4-beta-D-glucans and related oligosaccharides. Cellobiose is hydrolysed, but very slowly.
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CAS REGISTRY NUMBER
COMMENTARY
37288-52-1
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2-nitrophenyl beta-cellobioside + H2O
2-nitrophenol + beta-cellobiose
-
3.1% activity compared to 4-nitrophenyl beta-D-glucopyranoside
-
-
?
4-methylumbelliferyl 4-O-(beta-D-glucopyranosyl)-beta-D-xylopyranoside + H2O
?
-
-
-
-
?
4-methylumbelliferyl beta-cellotrioside + H2O
4-methylumbelliferone + cellotriose
-
-
-
-
?
4-methylumbelliferyl beta-D-cellobioside + 2 H2O
4-methylumbelliferol + 2 D-glucose
i.e.MuC, 14.9% relative activity compared to 4-nitrophenyl-beta-D-glucopyranoside as substrate
-
-
?
4-methylumbelliferyl beta-D-cellotrioside + H2O
4-methylumbelliferone + cellotriose
-
-
-
?
4-methylumbelliferyl beta-D-glucopyranoside + H2O
4-methylumbelliferone + D-glucopyranose
-
-
-
-
?
4-methylumbelliferyl-beta-D-cellobioside + H2O
D-glucose + ?
i.e.MuC, 157.7% relative activity compared to 4-nitrophenyl beta-D-glucopyranoside as substrate
-
-
?
4-methylumbelliferyl-beta-D-lactoside + H2O
4-methylumbelliferone + D-lactose
-
-
-
-
?
4-nitrophenyl beta-cellobioside + H2O
4-nitrophenol + beta-cellobiose
-
6.5% activity compared to 4-nitrophenyl beta-D-glucopyranoside
-
-
?
4-nitrophenyl beta-D-galactopyranoside + H2O
4-nitrophenol + beta-D-galactopyranose
-
1.2% activity compared to 4-nitrophenyl beta-D-glucopyranoside
-
-
?
4-nitrophenyl beta-D-glucopyranose + H2O
4-nitrophenol + D-glucose
-
-
-
?
4-nitrophenyl beta-D-glucopyranoside + H2O
4-nitrophenol + D-glucose
-
-
-
?
acid swollen cellulose + H2O
D-glucose + ?
-
-
-
?
alpha-cellulose + H2O
?
-
no activity with carboxymethylcellulose, salicin, cellobiose and alpha-dimethylglucoside
-
-
?
avicel + H2O
cellobiose + ?
-
0.09% activity compared to carboxymethylcellulose
-
-
?
barley beta-D-glucan + H2O
D-glucose
-
strongest activity (15525% activity compared to carboxymethyl cellulose)
-
-
?
barley glucan + H2O
?
-
326% activity compared to carboxymethylcellulose
-
-
?
carboxymethyl cellulose + H2O
cellobiose + cellopentaose + cellotetraose + cellotriose + D-glucose
-
-
the major product is cellobiose with some minor products
-
?
cellohexaose + H2O
cellopentaose + D-glucose
-
-
-
?
cellotetraose + H2O
cellobiose + cellotriose + D-glucose
-
-
cellobiose is the dominant product, while cellotriose and glucose are minor products
-
?
cellotetraose + H2O
glucose + cellobiose + cellotriose
-
with a conversion ratio of 80%
-
?
filter paper + H2O
cellobiose + cellopentaose + cellotetraose + cellotriose + D-glucose
-
-
the major product is cellobiose with some minor products
-
?
hydroquinone-beta-D-glucopyranoside + H2O
hydroquinone + D-glucose
-
-
-
?
hydroxyethyl cellulose + H2O
?
-
220% activity compared to carboxymethyl cellulose
-
-
?
n-heptyl-beta-D-glucopyranoside + H2O
n-heptanol + D-glucose
-
-
-
?
n-hexyl-beta-D-glucopyranoside + H2O
n-hexanol + D-glucose
-
-
-
?
n-octyl-beta-D-glucopyranoside + H2O
n-octanol + D-glucose
-
-
-
?
n-pentyl-beta-D-glucopyranoside + H2O
n-pentanol + D-glucose
-
-
-
?
oat spelt xylan + H2O
?
-
57% activity compared to carboxymethyl cellulose
-
-
?
p-nitrophenol beta-D-cellobioside + H2O
p-nitrophenol beta-D-glucopyranoside + D-glucose
-
-
-
?
p-nitrophenyl glucoside + H2O
p-nitrophenyl + glucose
-
p-nitrophenyl releasing with no lag period, no activity with p-nitrophenyl-?-(N-acetylgalactosamine), p-nitrophenyl-?-glucose-6-phosphate, p-nitrophenyl-(N-acetylglucosamine), p-nitrophenyl-di(N-acetylglucosamine), p-nitrophenyl-tri(N-acetylglucosamine)
-
-
?
p-nitrophenyl-beta-D-cellobiose + H2O
p-nitrophenol + cellobioside
-
-
-
?
p-nitrophenyl-beta-D-cellobioside + H2O
cellobiose + p-nitrophenol
-
-
-
ir
p-nitrophenyl-beta-D-cellotrioside + H2O
D-glucose + p-nitrophenyl-beta-D-cellobioside + p-nitrophenyl-beta-D-cellotetraoside + p-nitrophenyl-beta-D-glucoside
p-nitrophenyl-beta-D-fucopyranoside + H2O
p-nitrophenol + fucopyranose
-
-
-
?
phosphate acid swollen cellulose + H2O
?
-
10.7% activity compared to carboxymethylcellulose
-
-
?
2-nitrophenyl beta-D-galactopyranoside + H2O
2-nitrophenol + D-galactose
0.8% relative activity compared to 4-nitrophenyl beta-D-glucopyranoside as substrate
-
-
?
2-nitrophenyl beta-D-galactopyranoside + H2O
2-nitrophenol + D-galactose
1.3% relative activity compared to 4-nitrophenyl beta-D-glucopyranoside as substrate
-
-
?
2-nitrophenyl beta-D-glucopyranoside + H2O
2-nitrophenol + D-glucopyranose
-
25.2% activity compared to 4-nitrophenyl beta-D-glucopyranoside
-
-
?
2-nitrophenyl beta-D-glucopyranoside + H2O
2-nitrophenol + D-glucopyranose
-
25.2% activity compared to 4-nitrophenyl beta-D-glucopyranoside
-
-
?
4-methylumbelliferyl beta-cellobioside + H2O
4-methylumbelliferone + cellobiose
-
-
-
-
?
4-methylumbelliferyl beta-cellobioside + H2O
4-methylumbelliferone + cellobiose
-
-
-
-
?
4-methylumbelliferyl beta-D-glucoside + H2O
4-methylumbelliferone + D-glucopyranose
-
-
-
-
?
4-methylumbelliferyl beta-D-glucoside + H2O
4-methylumbelliferone + D-glucopyranose
-
-
-
-
?
4-methylumbelliferyl beta-D-glucoside + H2O
4-methylumbelliferone + D-glucopyranose
-
-
-
-
?
4-nitrophenyl alpha-D-glucopyranoside + H2O
4-nitrophenol + D-glucose
-
-
-
-
?
4-nitrophenyl alpha-D-glucopyranoside + H2O
4-nitrophenol + D-glucose
[Humicola] grisea var. thermoidea IFO 9854
-
-
-
-
?
4-nitrophenyl beta-D-cellobioside + H2O
4-nitrophenol + beta-D-cellobiose
-
exo-beta-1,4-glucanase activity, 24.1% activity compared to carboxymethylcellulose
-
-
?
4-nitrophenyl beta-D-cellobioside + H2O
4-nitrophenol + beta-D-cellobiose
-
-
-
-
?
4-nitrophenyl beta-D-cellobioside + H2O
4-nitrophenol + beta-D-cellobiose
[Humicola] grisea var. thermoidea IFO 9854
-
-
-
-
?
4-nitrophenyl beta-D-glucopyranoside + H2O
4-nitropheno