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Information on EC 3.1.4.60 - pApA phosphodiesterase

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EC Tree
     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.4 Phosphoric-diester hydrolases
                3.1.4.60 pApA phosphodiesterase
IUBMB Comments
The enzyme, characterized from the Gram-positive bacterium Staphylococcus aureus, is a cytoplasmic protein that contains a DHH/DHHA1 domain. It can act on cyclic di-3',5'-adenylate with a much lower activity (cf. EC 3.1.4.59, cyclic-di-AMP phosphodiesterase). Activity requires Mn2+ and is inhibited by ppGpp.
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The enzyme appears in viruses and cellular organisms
Synonyms
BB0619, Dhhp, MSMEG_2630, pApA hydrolase, PDE, PDE2, SAUSA300_1650, SPD_1153, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
5'-O-phosphonoadenylyl-(3'->5')-adenosine + H2O = 2 AMP
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