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Ligand 5'-O-phosphonoadenylyl-(3'->5')-adenosine

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Natural Substrate (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.1.4.60

5'-O-phosphonoadenylyl-(3'->5')-adenosine + H2O = 2 AMP

750844, 751077

-

In Vivo Product in Enzyme-catalyzed Reactions (2 results)

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Show Natural Product (2 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.1.4.59

cyclic di-3',5'-adenylate + H2O = 5'-O-phosphonoadenylyl-(3'->5')-adenosine

-

-

3.1.4.60

cyclic di-3',5'-adenylate + H2O = 5'-O-phosphonoadenylyl-(3'->5')-adenosine

-

-

Substrate in Enzyme-catalyzed Reactions (2 results)

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Show Substrate (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.1.4.59

5'-O-phosphonoadenylyl-(3'->5')-adenosine + H2O = 2 AMP

750954

-

3.1.4.60

5'-O-phosphonoadenylyl-(3'->5')-adenosine + H2O = 2 AMP

750844, 751077, 750954, 774196

-

Product in Enzyme-catalyzed Reactions (2 results)

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Show Product (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.1.4.59

cyclic di-3',5'-adenylate + H2O = 5'-O-phosphonoadenylyl-(3'->5')-adenosine

-

-

3.1.4.60

cyclic di-3',5'-adenylate + H2O = 5'-O-phosphonoadenylyl-(3'->5')-adenosine

-

-

Inhibitor in Enzyme-catalyzed Reactions (1 result)

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Show Inhibitors (1 entry)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

3.1.4.59

product inhibition, competitive

749856

-

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (1 result)

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Show Turnover Number (1 entry)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

3.1.4.60

3527

-

pH 8.5, 37°C

774196

K_M Value (4 results)

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Show KM Value (4 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

3.1.4.59

0.0167

-

pH 7.5, 37°C

750954

3.1.4.59

0.0364

-

pH 7.5, 37°C

750954

3.1.4.60

0.0239

-

pH 7.5, 37°C

750954

3.1.4.60

0.877

-

pH 8.5, 37°C

774196

3.1.4.59

2 entries

3.1.4.60

2 entries

References & Links

Literature References (8)

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Show Reference (8 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

749856

29203646

Structural and biochemical characterization of the catalytic domains of GdpP reveals a unified hydrolysis mechanism for the DHH/DHHA1 phosphodiesterase

2018

Wang, F.; He, Q.; Su, K.; Wei, T.; Xu, S.; Gu, L.

Biochem. J.

475

191-205

750844

26078723

Functional analysis of a c-di-AMP-specific phosphodiesterase MsPDE from Mycobacterium smegmatis

2015

Tang, Q.; Luo, Y.; Zheng, C.; Yin, K.; Ali, M.; Li, X.; He, J.

Int. J. Biol. Sci.

11

813-824

750844

26078723

Functional analysis of a c-di-AMP-specific phosphodiesterase MsPDE from Mycobacterium smegmatis

2015

Tang, Q.; Luo, Y.; Zheng, C.; Yin, K.; Ali, M.; Li, X.; He, J.

Int. J. Biol. Sci.

11

813-824

750954

24013631

Two DHH subfamily 1 proteins in Streptococcus pneumoniae possess cyclic di-AMP phosphodiesterase activity and affect bacterial growth and virulence

2013

Bai, Y.; Yang, J.; Eisele, L.E.; Underwood, A.J.; Koestler, B.J.; Waters, C.M.; Metzger, D.W.; Bai, G.

J. Bacteriol.

195

5123-5132

750954

24013631

Two DHH subfamily 1 proteins in Streptococcus pneumoniae possess cyclic di-AMP phosphodiesterase activity and affect bacterial growth and virulence

2013

Bai, Y.; Yang, J.; Eisele, L.E.; Underwood, A.J.; Koestler, B.J.; Waters, C.M.; Metzger, D.W.; Bai, G.

J. Bacteriol.

195

5123-5132

751077

27834680

New insights into the cyclic di-adenosine monophosphate (c-di-AMP) degradation pathway and the requirement of the cyclic dinucleotide for acid stress resistance in Staphylococcus aureus

2016

Bowman, L.; Zeden, M.S.; Schuster, C.F.; Kaever, V.; Gruendling, A.

J. Biol. Chem.

291

26970-26986

751077

27834680

New insights into the cyclic di-adenosine monophosphate (c-di-AMP) degradation pathway and the requirement of the cyclic dinucleotide for acid stress resistance in Staphylococcus aureus

2016

Bowman, L.; Zeden, M.S.; Schuster, C.F.; Kaever, V.; Gruendling, A.

J. Biol. Chem.

291

26970-26986

750844

2 entries

750954

2 entries

751077

2 entries

774196

32825526

Cyclic di-adenosine monophosphate regulates metabolism and growth in the oral commensal Streptococcus mitis

2020

Rorvik, G.H.; Liskiewicz, K.A.; Kryuchkov, F.; Naemi, A.O.; Aasheim, H.C.; Petersen, F.C.; Kuentziger, T.M.; Simm, R.

Microorganisms

8

1269

Links to other databases for 5'-O-phosphonoadenylyl-(3'->5')-adenosine

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Show Links (1 entry)