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Information on EC 3.1.3.3 - phosphoserine phosphatase
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3.1.3.3 phosphoserine phosphataseSpecify your search results
Word Map
- 3.1.3.3
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supranuclear
- palsy
- atrophy
- degeneration
- neurodegenerative
- tau
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corticobasal
- dementia
- alzheimer
-
parkinsonian
-
frontal
-
shellfish
- pneumothorax
-
paralytic
-
neurofibrillary
-
neuropathological
- tauopathies
- tangle
-
poison
-
frontotemporal
- midbrain
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postsynaptic
- chest
-
gaze
-
subcortical
-
dinoflagellate
-
video-assisted
-
thoracoscopic
-
saxitoxin
-
postural
-
pseudopregnancy
- levodopa
-
richardson
-
voxel-based
-
monosynaptic
-
subthalamic
- bradykinesia
-
oculomotor
-
apathy
-
argyrophilic
-
precentral
-
pedunculopontine
- analysis
-
akinesia
-
saccade
- medicine
- apraxia
-
updrs
- bulla
-
tegmentum
-
peduncle
-
pleurodesis
The enzyme appears in viruses and cellular organisms
Synonyms
psp, serine/threonine protein phosphatase, phosphoserine phosphatase, pspase, ctd phosphatase fcp1, serb653, serb2, l-phosphoserine phosphatase, 3-phosphoserine phosphatase, ipsp1, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
3-phosphoserine phosphatase
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CTD phosphatase fcp1
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iPSP
iPSP1
iPSP2
metal-independent phosphoserine phosphatase
metal-independent PSP
O-phosphoserine phosphohydrolase
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-
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phosphatase, phosphoserine
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-
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phosphoserine phosphatase
PP1
PSP
pspA
PSPase
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-
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pspB
PSPH
RsbP
RsbU
RsbX
SerB2
serine/threonine protein phosphatase
StP
additional information
PSP
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-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
O-phospho-L(or D)-serine + H2O = L(or D)-serine + phosphate
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of phosphoric ester
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-
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PATHWAY SOURCE
PATHWAYS
BRENDA
KEGG
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SYSTEMATIC NAME
IUBMB Comments
O-phosphoserine phosphohydrolase
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CAS REGISTRY NUMBER
COMMENTARY
9025-73-4
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
O-phospho-L-threonine + H2O
L-threonine + phosphate
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lowest activity
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-
?
p-nitrophenyl phosphate + H2O
p-nitrophenol + phosphate
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-
-
?
L-3-phosphoserine + H2O
L-serine + phosphate
biosynthesis of serine, terminal enzyme in the plastidic pathway
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-
?
L-3-phosphoserine + H2O
L-serine + phosphate
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final step in serine biosynthesis
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-
?
L-3-phosphoserine + H2O
L-serine + phosphate
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final step in serine biosynthesis
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-
?
L-3-phosphoserine + H2O
L-serine + phosphate
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final step in serine biosynthesis
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-
?
L-3-phosphoserine + H2O
L-serine + phosphate
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final step in serine biosynthesis
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-
?
L-O-phosphoserine + H2O
L-serine + phosphate
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enzyme is responsible for the third and final step of the L-serine biosynthetic pathway
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?
L-phosphoserine + H2O
L-serine + phosphate
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strict substrate specificity for L-phosphoserine
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?
L-phosphoserine + H2O
L-serine + phosphate
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strict substrate specificity for L-phosphoserine
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?
L-phosphoserine + H2O
L-serine + phosphate
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-
-
?
O-phospho-D-serine + H2O
D-serine + phosphate
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-
-
?
O-phospho-L(or D)-serine + H2O
L(or D)-serine + phosphate
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-
-
?
O-phospho-L(or D)-serine + H2O
L(or D)-serine + phosphate
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-
-
?
O-phospho-L-serine + H2O
L-serine + phosphate
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-
-
-
?
O-phospho-L-serine + H2O
L-serine + phosphate
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-
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?
O-phospho-L-serine + H2O
L-serine + phosphate
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-
-
?
O-phospho-L-serine + H2O
L-serine + phosphate
the enzyme catalyzes the final and irreversible step of L-serine synthesis
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ir
[RsbS]-serine/threonine phosphate + H2O
[RsbS]-serine/threonine + phosphate
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-
-
?
[RsbS]-serine/threonine phosphate + H2O
[RsbS]-serine/threonine + phosphate
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-
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?
[RsbV]-serine/threonine phosphate + H2O
[RsbV]-serine/threonine + phosphate
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-
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?
[RsbV]-serine/threonine phosphate + H2O
[RsbV]-serine/threonine + phosphate
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-
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?
[TsbR]-serine/threonine phosphate + H2O
[TsbR]-serine/threonine + phosphate
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-
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?
[TsbR]-serine/threonine phosphate + H2O
[TsbR]-serine/threonine + phosphate
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?
additional information
?
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poor substrates: D-phosphoserine, DL-phosphothreonine, 3-phosphoglycerate, 4-nitrophenylphosphate, and fructose-6-phosphate. Enzyme does not display phosphoglycerate mutase activity
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?
additional information
?
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poor substrates: D-phosphoserine, DL-phosphothreonine, 3-phosphoglycerate, 4-nitrophenylphosphate, and fructose-6-phosphate. Enzyme does not display phosphoglycerate mutase activity
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?
additional information
?
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poor substrates: D-phosphoserine, DL-phosphothreonine, 3-phosphoglycerate, 4-nitrophenylphosphate, and fructose-6-phosphate. Enzyme does not display phosphoglycerate mutase activity
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?
additional information
?
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poor substrates: D-phosphoserine, DL-phosphothreonine, 3-phosphoglycerate, 4-nitrophenylphosphate, and fructose-6-phosphate. Enzyme does not display phosphoglycerate mutase activity
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?
additional information
?
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poor substrates: D-phosphoserine, DL-phosphothreonine, 3-phosphoglycerate, 4-nitrophenylphosphate, and fructose-6-phosphate. Enzyme does not display phosphoglycerate mutase activity
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?
additional information
?
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no substrate: O-phospho-L-threonine
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?
additional information
?
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no substrate: O-phospho-L-threonine
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?
additional information
?
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no substrate: O-phospho-L-threonine
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?
additional information
?
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the enzyme may play a role in altered neuronal function in Alzheimers disease via enhancing glutamate-induced neurotoxicity by D-serine and the IL-11 receptor system
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?
additional information
?
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no activity with O-phospho-L-tyrosine, 4-nitrophenyl phosphate, pyridoxal 5'-phosphate, D-glucose 6-phosphate, an D-fructose 6-phosphate
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-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
L-O-phosphoserine + H2O
L-serine + phosphate
-
enzyme is responsible for the third and final step of the L-serine biosynthetic pathway
-
?
additional information
?
-
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the enzyme may play a role in altered neuronal function in Alzheimers disease via enhancing glutamate-induced neurotoxicity by D-serine and the IL-11 receptor system
-
?
L-3-phosphoserine + H2O
L-serine + phosphate
biosynthesis of serine, terminal enzyme in the plastidic pathway
-
-
?
L-3-phosphoserine + H2O
L-serine + phosphate
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final step in serine biosynthesis
-
-
?
L-3-phosphoserine + H2O
L-serine + phosphate
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final step in serine biosynthesis
-
-
?
L-3-phosphoserine + H2O
L-serine + phosphate
-
final step in serine biosynthesis
-
-
?
L-3-phosphoserine + H2O
L-serine + phosphate
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final step in serine biosynthesis
-
-
?
O-phospho-D-serine + H2O
D-serine + phosphate
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-
-
?
O-phospho-L(or D)-serine + H2O
L(or D)-serine + phosphate
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?
O-phospho-L(or D)-serine + H2O
L(or D)-serine + phosphate
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?
O-phospho-L-serine + H2O
L-serine + phosphate
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?
O-phospho-L-serine + H2O
L-serine + phosphate
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?
O-phospho-L-serine + H2O
L-serine + phosphate
the enzyme catalyzes the final and irreversible step of L-serine synthesis
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ir
[RsbS]-serine/threonine phosphate + H2O
[RsbS]-serine/threonine + phosphate
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-
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?
[RsbS]-serine/threonine phosphate + H2O
[RsbS]-serine/threonine + phosphate
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-
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?
[RsbV]-serine/threonine phosphate + H2O
[RsbV]-serine/threonine + phosphate
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-
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?
[RsbV]-serine/threonine phosphate + H2O
[RsbV]-serine/threonine + phosphate
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-
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?
[TsbR]-serine/threonine phosphate + H2O
[TsbR]-serine/threonine + phosphate
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-
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?