BRENDA - Enzyme Database show
show all sequences of 3.1.3.3

Phosphoserine phosphatase of human brain: partial purification, characterization, regional distribution, and effect of certain modulators including psychoactive drugs

Shetty, V.; Shetty, K.T.; Neurochem. Res. 16, 1203-1210 (1991)
No PubMed abstract available

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
Chlordiazepoxide
activation
Homo sapiens
diazepam
activation
Homo sapiens
sucrose
activation
Homo sapiens
Inhibitors
Inhibitors
Commentary
Organism
Structure
Ca2+
-
Homo sapiens
chlorpromazine
-
Homo sapiens
F-
-
Homo sapiens
Mn2+
-
Homo sapiens
Trifluorperazine
-
Homo sapiens
vanadate
-
Homo sapiens
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.036
-
L-phosphoserine
-
Homo sapiens
0.1
-
D-phosphoserine
-
Homo sapiens
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Cu2+
activation
Homo sapiens
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
-
-
Purification (Commentary)
Commentary
Organism
partially
Homo sapiens
Source Tissue
Source Tissue
Commentary
Organism
Textmining
brain
cortex, brain stem, cerebellum, striatum, thalamus hippocampus
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
beta-glycerophosphate + H2O
-
81054
Homo sapiens
glycerol + phosphate
-
81054
Homo sapiens
?
D-fructose 6-phosphate + H2O
-
81054
Homo sapiens
D-fructose + phosphate
-
81054
Homo sapiens
?
D-phosphoserine + H2O
-
81054
Homo sapiens
D-Ser + phosphate
-
81054
Homo sapiens
?
L-phosphoserine + H2O
-
81054
Homo sapiens
L-Ser + phosphate
-
81054
Homo sapiens
?
O-phospho-L-tyrosine + H2O
-
81054
Homo sapiens
L-Tyr + phosphate
-
81054
Homo sapiens
?
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
5.6
6.6
-
Homo sapiens
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
Chlordiazepoxide
activation
Homo sapiens
diazepam
activation
Homo sapiens
sucrose
activation
Homo sapiens
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
Ca2+
-
Homo sapiens
chlorpromazine
-
Homo sapiens
F-
-
Homo sapiens
Mn2+
-
Homo sapiens
Trifluorperazine
-
Homo sapiens
vanadate
-
Homo sapiens
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.036
-
L-phosphoserine
-
Homo sapiens
0.1
-
D-phosphoserine
-
Homo sapiens
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Cu2+
activation
Homo sapiens
Purification (Commentary) (protein specific)
Commentary
Organism
partially
Homo sapiens
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
brain
cortex, brain stem, cerebellum, striatum, thalamus hippocampus
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
beta-glycerophosphate + H2O
-
81054
Homo sapiens
glycerol + phosphate
-
81054
Homo sapiens
?
D-fructose 6-phosphate + H2O
-
81054
Homo sapiens
D-fructose + phosphate
-
81054
Homo sapiens
?
D-phosphoserine + H2O
-
81054
Homo sapiens
D-Ser + phosphate
-
81054
Homo sapiens
?
L-phosphoserine + H2O
-
81054
Homo sapiens
L-Ser + phosphate
-
81054
Homo sapiens
?
O-phospho-L-tyrosine + H2O
-
81054
Homo sapiens
L-Tyr + phosphate
-
81054
Homo sapiens
?
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
5.6
6.6
-
Homo sapiens
Other publictions for EC 3.1.3.3
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
750531
Chiba
Discovery and analysis of a n ...
Thermus thermophilus
FEBS J.
286
726-736
2018
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1
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1
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1
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6
1
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1
-
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-
-
750674
Samuilov
Knock-down of the phosphoseri ...
Arabidopsis thaliana
Front. Plant Sci.
9
1830
2018
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1
1
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750864
Janczarek
Hanks-type Serine/threonine p ...
Bacillus subtilis 168, Bacillus subtilis
Int. J. Mol. Sci.
19
2872-2901
2018
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14
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6
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14
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2
6
-
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751628
Krachtus
Quantum mechanical/molecular ...
Methanocaldococcus jannaschii, Methanocaldococcus jannaschii ATCC 43067
Molecules
23
3342
2018
-
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1
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1
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4
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749588
Sato
Phosphoserine phosphatase is ...
Homo sapiens
Anticancer Res.
37
2365-2371
2017
-
1
-
-
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-
-
-
-
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1
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1
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1
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749921
Grant
Regulatory mechanism of Mycob ...
Mycobacterium tuberculosis
Biochemistry
56
6481-6490
2017
-
-
1
-
2
-
2
1
-
1
-
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-
3
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2
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-
1
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1
1
750969
Kim
Phosphoserine phosphatase is ...
Hydrogenobacter thermophilus, Hydrogenobacter thermophilus TK-6
J. Bacteriol.
199
e00409-17
2017
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5
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749807
Li
Inhibition of phosphoserine p ...
Homo sapiens
Biochem. Biophys. Res. Commun.
477
633-639
2016
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1
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750095
Kim
Discovery of an intermolecula ...
Hydrogenobacter thermophilus, Hydrogenobacter thermophilus DSM 6534
Biosci. Biotechnol. Biochem.
80
232-240
2016
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1
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-
752146
Ozeki
Phosphoserine phosphatase act ...
Homo sapiens
Psychiatry Res.
237
344-350
2016
-
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1
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1
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-
730055
Arora
High throughput screen identif ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618
J. Biol. Chem.
289
25149-25165
2014
1
1
1
1
6
-
5
1
-
2
1
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5
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1
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1
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1
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6
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5
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4
1
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1
1
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1
1
728781
Jung
Identification of a novel liga ...
Thermococcus onnurineus
Proteins
81
819-829
2013
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-
1
1
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1
5
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4
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1
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2
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1
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1
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5
5
730011
Chiba
Structural units important for ...
Hydrogenobacter thermophilus, Hydrogenobacter thermophilus DSM 6534
J. Biol. Chem.
288
11448-11458
2013
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-
1
1
4
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4
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8
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3
3
730605
Cascales-Minana
The phosphorylated pathway of ...
Arabidopsis thaliana
Plant Cell
25
2084-2101
2013
-
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1
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728901
Chiba
Crystallization and preliminar ...
Hydrogenobacter thermophilus, Hydrogenobacter thermophilus TK-6 / IAM 12695
Acta Crystallogr. Sect. F
68
911-913
2012
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-
1
1
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729978
Chiba
Discovery and analysis of cofa ...
Hydrogenobacter thermophilus, Hydrogenobacter thermophilus DSM 6534
J. Biol. Chem.
287
11934-11941
2012
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702981
Pollari
Enhanced serine production by ...
Homo sapiens
Breast Cancer Res. Treat.
125
421-430
2011
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715741
Bachelor
L-3-Phosphoserine phosphatase ...
Homo sapiens
J. Dermatol. Sci.
63
164-172
2011
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1
1
1
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715162
Bainbridge
Role of Porphyromonas gingival ...
Porphyromonas gingivalis
Infect. Immun.
78
4560-4569
2010
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1
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701654
Antflick
The effects of a low protein d ...
Mus musculus, Mus musculus C57BL/6
Amino Acids
39
145-153
2009
-
-
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-
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3
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1
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702967
Antflick
L-Serine-O-phosphate in the ce ...
Rattus norvegicus
Brain Res.
1300
1-13
2009
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1
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1
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5
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1
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692760
Baxter
Anionic charge is prioritized ...
Methanocaldococcus jannaschii
J. Am. Chem. Soc.
130
3952-3958
2008
-
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2
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4
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682867
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Phosphoserine phosphatase is e ...
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Crystal structure of phosphose ...
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BeF(3)(-) acts as a phosphate ...
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651355
Nishiyama
A chromosomal locus encoding a ...
Streptomyces azureus, Streptomyces azureus ATCC 14921
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Heese
Induction of rat L-phosphoseri ...
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Ho
Plastidic pathway of serine bi ...
Arabidopsis thaliana
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81056
Hawkinson
Novel phosphoserine phosphatas ...
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81055
Wood
Formation of D-serine from L-p ...
Rattus norvegicus
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81054
Shetty
-
Phosphoserine phosphatase of h ...
Homo sapiens
Neurochem. Res.
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3
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81049
Kearney
-
Regulation and routes of biosy ...
Methylophilus methylotrophus, Rattus norvegicus
FEMS Microbiol. Lett.
42
109-112
1987
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81051
Walton
Enzymes of serine and glycine ...
Pisum sativum
Planta
167
119-128
1986
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81041
Vidal
-
Interactions of aminophosphona ...
Rattus norvegicus
Biochem. Soc. Trans.
13
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1985
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81042
Garnant
Construction and analysis of p ...
Escherichia coli
Mol. Gen. Genet.
193
72-75
1984
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1
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81043
Paoli
O-Phosphoserine phosphatase fr ...
Bos taurus
Biochim. Biophys. Acta
370
487-497
1974
-
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1
2
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1
1
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1
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1
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2
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81044
Schmidt
Enzymes of serine biosynthesis ...
Rhodobacter capsulatus
Arch. Biochem. Biophys.
159
475-482
1973
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1
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81045
Bridgers
Purification of mouse brain ph ...
Mus musculus
Arch. Biochem. Biophys.
133
201-207
1969
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1
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1
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1
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1
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2
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1
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81046
Knox
Phosphoserine phosphatase dist ...
Rattus norvegicus
Arch. Biochem. Biophys.
132
397-403
1969
-
-
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1
4
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1
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1
2
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-
1
2
-
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-
-
-
-
-
-
-
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81052
Germano
Serine biosynthesis in Desulfo ...
Desulfovibrio desulfuricans
J. Bacteriol.
99
893-894
1969
-
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1
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2
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-
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81047
Bridgers
Mouse brain phosphoserine phos ...
Mus musculus
J. Biol. Chem.
242
2080-2085
1967
-
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5
1
1
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1
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1
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1
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1
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5
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1
1
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1
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1
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-
-
-
-
1
-
-
-
-
-
-
-
-
-
81048
Byrne
-
Glucose 6-phosphatase and phos ...
Gallus gallus, Rattus norvegicus
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
5
73-78
1961
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6
2
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2
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4
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1
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6
-
2
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4
-
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-
1
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-
-
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-
81050
Neuhaus
Metabolism of phosphoserine. I ...
Gallus gallus
J. Biol. Chem.
234
113-121
1959
-
-
-
-
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6
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5
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1
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1
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-
1
1
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4
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-
1
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6
-
3
-
5
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1
-
1
1
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4
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1
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