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Information on EC 2.7.1.94 - acylglycerol kinase and Organism(s) Homo sapiens and UniProt Accession Q53H12
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2.7.1.94 acylglycerol kinaseIUBMB Comments
Acts on both 1- and 2-acylglycerols.
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Word Map
- 2.7.1.94
- translocase
-
intermembrane
-
lysophosphatidic
-
sengers
-
phosphatidic
- monoacylglycerols
- preproteins
- tim10
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polytopic
- presequence
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lpa-induced
- medicine
- autotaxin
- diagnostics
- drug development
The taxonomic range for the selected organisms is: Homo sapiens
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
tim22 complex, acylglycerol kinase, 1-mgk, 2-mgk, monoacylglycerol kinase, multisubstrate lipid kinase, monoglyceride kinase, 1-monoacylglycerol kinase, 
more
topSYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
TIM22 complex
the enzyme mutated in Sengers syndrome is identified as a subunit of the TIM22 complex
kinase, monoacylglycerol (phosphorylating)
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MGK
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monoacylglycerol kinase
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monoglyceride kinase
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monoglyceride phosphokinase
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sn-2-monoacylglycerol kinase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phospho group transfer
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PATHWAY SOURCE
PATHWAYS
SYSTEMATIC NAME
IUBMB Comments
ATP:acylglycerol 3-phosphotransferase
Acts on both 1- and 2-acylglycerols.
CAS REGISTRY NUMBER
COMMENTARY
62213-37-0
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + 1,2-dioleoyl-sn-glycerol
ADP + 1,2-dioleoyl-sn-glycerol 3-phosphate
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recombinant enzyme
-
-
?
ATP + 1-oleoyl-sn-glycerol
ADP + 1-oleoyl-sn-glycerol 3-phosphate
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recombinant enzyme
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-
?
ATP + 1-palmitoyl-sn-glycerol
ADP + 1-palmitoyl-sn-glycerol 3-phosphate
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recombinant enzyme
-
-
?
ATP + 1-stearoyl-sn-glycerol
ADP + 1-stearoyl-sn-glycerol 3-phosphate
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recombinant enzyme
-
-
?
ATP + 2-arachidonoyl glycerol
ADP + 2-arachidonoylglycerol 3-phosphate
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-
-
-
?
ATP + acylglycerol
ADP + acyl-sn-glycerol 3-phosphate
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the enzyme acts on both 1- and 2-acylglycerols, substrate specificity, overview
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-
?
ATP + 2-arachidonoyl-glycerol
ADP + 2-arachidonoyl-glycerol 3-phosphate
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-
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?
ATP + 2-arachidonoyl-glycerol
ADP + 2-arachidonoyl-glycerol 3-phosphate
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recombinant enzyme
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-
?
ATP + diacylglycerol
ADP + phosphatidic acid
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i.e. diacyl-glycerol 3-phosphate, regulation mechanism, overview
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?
ATP + diacylglycerol
ADP + phosphatidic acid
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i.e. diacyl-glycerol 3-phosphate
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?
ATP + monoacylglycerol
ADP + lysophosphatidic acid
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i.e. acyl-sn-glycerol 3-phosphate, regulation mechanism, overview
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?
ATP + monoacylglycerol
ADP + lysophosphatidic acid
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i.e. acyl-sn-glycerol 3-phosphate
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?
additional information
?
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lysophosphatidic acid induces the cytokine interleukin-8 correlated with angiogenesis, tumorigenicity, and cancer cell proliferation, the enzyme modulates cross talk with EGFR in prostate cancer cells, enzyme regulates the synthesis of the bioactive phospholipids lysophosphatidic acid and phosphatidic acid, activation of extracellular signal related kinase 1 and 2, thus being involved in pathenogenesis of cancer via enhanced cell proliferation
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?
additional information
?
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the enzyme plays a critical role in epidermal growth factor-induced mitogenesis of prostate cancer cells via EGF and IFG-II, and lysophosphatidic acid, the first way can be inhibited by enzyme suppression, the second cannot, enzyme function and regulation in initiation and progression of prostate cancer, lysophosphatidic acid enhances surival and suppresses apoptosis by reducing levels of the apoptosis-promoting protein Bax, and is involved in signal transduction pathways, overview
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?
additional information
?
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no activity by the recombinant enzyme with C6-ceramide and sphingosine
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?
additional information
?
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in addition to its main activity, phosphorylation of 1,2-diacyl-sn-glycerol to 1,2-diacyl-sn-glycerol 3-phosphate, EC 2.7.1.107, the enzyme also shows acylglycerol kinase activity, EC 2.7.1.94. Both monoacylglycerol kinase activities are low
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?
additional information
?
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in addition to its main activity, phosphorylation of 1,2-diacyl-sn-glycerol to 1,2-diacyl-sn-glycerol 3-phosphate, EC 2.7.1.107, the enzyme also shows acylglycerol kinase activity, EC 2.7.1.94. Both monoacylglycerol kinase activities are very low
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?
additional information
?
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in addition to its main activity, phosphorylation of 1,2-diacyl-sn-glycerol to 1,2-diacyl-sn-glycerol 3-phosphate, EC 2.7.1.107, the enzyme also shows acylglycerol kinase activity, EC 2.7.1.94. The 2-MGK activity is very low
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-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + diacylglycerol
ADP + phosphatidic acid
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-
i.e. diacyl-glycerol 3-phosphate, regulation mechanism, overview
-
?
ATP + monoacylglycerol
ADP + lysophosphatidic acid
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i.e. acyl-sn-glycerol 3-phosphate, regulation mechanism, overview
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?
additional information
?
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lysophosphatidic acid induces the cytokine interleukin-8 correlated with angiogenesis, tumorigenicity, and cancer cell proliferation, the enzyme modulates cross talk with EGFR in prostate cancer cells, enzyme regulates the synthesis of the bioactive phospholipids lysophosphatidic acid and phosphatidic acid, activation of extracellular signal related kinase 1 and 2, thus being involved in pathenogenesis of cancer via enhanced cell proliferation
-
-
?
additional information
?
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the enzyme plays a critical role in epidermal growth factor-induced mitogenesis of prostate cancer cells via EGF and IFG-II, and lysophosphatidic acid, the first way can be inhibited by enzyme suppression, the second cannot, enzyme function and regulation in initiation and progression of prostate cancer, lysophosphatidic acid enhances surival and suppresses apoptosis by reducing levels of the apoptosis-promoting protein Bax, and is involved in signal transduction pathways, overview
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?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
octyl-beta-glucopyranoside
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inhibits the recombinant enzyme in cell extract of transfected NIH 3T3 cells
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
enzyme overexpression in early stage
enzyme AGK is significantly upregulated in NPC cell lines and clinical specimens as indicated by real-time PCR and Western blotting, overview
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proliferative diabetic retinopathy and proliferative vitreoretinopathy epiretinal membranes
additional information
additional information
quantitative real-time PCR expression analysis of AGK in six cervical cancer cell lines and four paired early stage CSCC specimens and normal cervical tissues, overview
additional information
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quantitative real-time PCR expression analysis of AGK in six cervical cancer cell lines and four paired early stage CSCC specimens and normal cervical tissues, overview
additional information
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no expression in ovary, lung, small intestine, and thymus
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
-
proliferative diabetic retinopathy and proliferative vitreoretinopathy epiretinal membranes
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
malfunction
metabolism
the enzyme has a dual function in protein translocation and lipid biosynthesis
physiological function
evolution
malfunction
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presence or absence of 1-MGK and 2-MGK activities may be essential to the pathophysiological functions of each DGK isozyme
malfunction
cell proliferation and cell cycle progression of an established voral squamous cell carcinoma cell, OSCC, cell line are decreased following enzyme AGK knockdown, and are enhanced by enzyme AGK overexpression in vitro. Aberrant AGK expression in OSCC is associated with cell proliferation and cell cycle progression. Knockdown of AGK results in reduced mRNA and protein expression levels of cyclin D1 and p-Rb, whereas the expression levels of p21 are increased
malfunction
enzyme overexpression significantly enhances, whereas silencing endogenous enzyme AGK inhibits the proliferation and tumorigenicity of breast cancer cells both in vitro and in vivo. Overexpression of AGK enhances G1-S phase transition in breast cancer cells, which is associated with activation of AKT, suppression of FOXO1 transactivity, downregulation of cyclin-dependent kinase inhibitors p21Cip1 and p27Kip1 and upregulation of the cell cycle regulator cyclin D1
malfunction
silencing the expression of the enzyme dramatically suppresses cell proliferation, migration and invasion of glioma cells in vitro
physiological function
acylglycerol kinase (AGK) is a multisubstrate lipid kinase, that catalyzes the production of lysophosphatidic acid and phosphatidic acid from monoacylglycerol and diacylglycerol. Acylglycerol kinase augments JAK2/STAT3 signaling in esophageal squamous cells, the enzyme AGK directly interacts with the JH2 domain to relieve inhibition of JAK2 and activate JAK2/STAT3 signaling. AGK levels significantly correlate with increased STAT3 phosphorylation, poorer disease-free survival, and shorter overall survival in primary esophageal squamous cell cancer cell, and AGK expression is significantly correlated with JAK2/STAT3 hyperactivation in esophageal squamous cell cancer cell, as well as in lung and breast cancer. Overexpression of AGK leads to activation of EGF receptor and promotes the proliferation and migration of prostate cancer cells, suggesting that AGK might act as a potent oncogene. AGK enhances JAK2 activity by blocking JH2-mediated autoinhibition of JAK2. Solid tumor cells override the autoinhibitory effect of JH2 to maintain activation of JAK2/STAT3 signaling, mechanism, overview. Enzyme AGK is a JH2 domain-interacting protein that activates the JAK2/STAT3 pathway
physiological function
acylglycerol kinase contributes to cancer progression and unfavorable clinical outcomes of patients with early-stage cervical squamous cell cancer. Early-stage cervical squamous cell cancer patients with high AGK expression level had shorter progress-free survival and overall survival time compared with patients with low AGK expression levels
physiological function
acylglycerol kinase is a multisubstrate lipid kinase, that is associated with the progression of various types of human cancer, it promotes proliferation and cell cycle progression of oral squamous cell carcinoma. Overexpression of AGK results in upregulation of the protein and mRNA expression levels of cyclin D1, and increases the expression levels of p-Rb, while p21 expression levels are downregulated. The enzyme may promote malignant cancer growth by regulating the expression of cyclin D1 and p21, during the G1-S phase transition
physiological function
acylglycerol kinase promotes cell proliferation and tumorigenicity in breast cancer via suppression of the FOXO1 transcription factor, FOXO1 is considered to be a tumor suppressor. The enzyme significantly correlates with patients' clinicopathologic characteristics, including clinical stage and tumor-nodule-metastasis (TNM) classification
physiological function
by acting as a lipid kinase, AGK catalyzes the phosphorylation of acylglycerol to generate lysophosphatidic acid , which is known to be involved in tumor progression, invasion, neovascularization, and metastasis. Overexpression of acylglycerol kinase is associated with poorer prognosis and lymph node metastasis in nasopharyngeal carcinoma. High expression of enzyme AGK is associated with significantly shorter overall and disease-free survival and is an independent prognostic factor for overall survival. High AGK expression is associated with lymph node metastasis and is an independent predicted factor for lymph node metastasis in nasopharyngeal carcinoma
physiological function
the enzyme plays an important role in the viability and motility of glioma cells. Enzyme upregulation is involved into glioma development and progression
physiological function
the kinase activity of the enzyme is dispensable for protein import but required for the structural integrity of mitochondria and apoptotic resistance. The enzyme functions as a subunit of the carrier translocase TIM22 complex independent of its kinase activity. The enzyme mutated in Sengers syndrome is a subunit of the TIM22 complex. The enzyme is required for the import of membrane proteins ANT1 and SLC25A24 into mitochondria
evolution
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comprehensive analysis on the 1-monoacylglycerol kinase (1-MGK) and 2-monoacylglycerol kinase (2-MGK) activities of ten diacylglyceol kinase (DGK) isozymes, EC 2.7.1.107, from different organisms. Type I (alpha, beta, and gamma), type II (delta, eta, and kappa) and type III (epsilon) DGKs have 7.9-19.2% 2-MGK activity compared to their DGK activities, whereas their 1-MGK activities are below 3.0%. Both the 1-MGK and 2-MGK activities of the type IV DGKs (lambda and iota) are below 1% relative to their DGK activities. Type V DGKtheta has approximately 6% 1-MGK activity and below 2% 2-MGK activity compared to its DGK activity. Purified DGKtheta exhibits the same results, indicating that its 1-MGK activity is intrinsic. DGK isozymes are categorized into three types with respect to their 1-MGK and 2-MGK activities: those having (1) 2-MGK activity relatively stronger than their 1-MGK activity (types I-III), (2) only negligible 1-MGK and 2-MGK activities (type IV), and (3) 1-MGK activity stronger than its 2-MGK activity (type V). The 1-MGK activity of DGKtheta and the 2-MGK activity of DGKalpha are stronger than those of the acylglycerol kinase reported as 1-MGK and 2-MGK to date
evolution
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comprehensive analysis on the 1-monoacylglycerol kinase (1-MGK) and 2-monoacylglycerol kinase (2-MGK) activities of ten diacylglyceol kinase (DGK) isozymes, EC 2.7.1.107, from different organisms. Type I (alpha, beta, and gamma), type II (delta, eta, and kappa) and type III (epsilon) DGKs have 7.9-19.2% 2-MGK activity compared to their DGK activities, whereas their 1-MGK activities are below 3.0%. Both the 1-MGK and 2-MGK activities of the type IV DGKs (zeta and iota) are below 1% relative to their DGK activities. Type V DGKtheta has approximately 6% 1-MGK activity and below 2% 2-MGK activity compared to its DGK activity. Purified DGKtheta exhibits the same results, indicating that its 1-MGK activity is intrinsic. DGK isozymes are categorized into three types with respect to their 1-MGK and 2-MGK activities: those having (1) 2-MGK activity relatively stronger than their 1-MGK activity (types I-III), (2) only negligible 1-MGK and 2-MGK activities (type IV), and (3) 1-MGK activity stronger than its 2-MGK activity (type V). The 1-MGK activity of DGKtheta and the 2-MGK activity of DGKalpha are stronger than those of the acylglycerol kinase reported as 1-MGK and 2-MGK to date
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). AGK_HUMAN
422
0
47137
Swiss-Prot
Secretory Pathway (Reliability: 5)
PDB
SCOP
CATH
UNIPROT
ORGANISM
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
G126E
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site-directed mutagenesis, mutation of the conserved glycine residue of the glycine-rich loop of the ATP binding site, catalytically inactive mutant
additional information
additional information
identification of a novel autosomal recessive cataract locus on 7q33-q36.1 in a multiplex consanguineous family with isolated congenital cataractl. Mutation is a splice-site mutation in AGK, encoding acylglycerol kinase, which leads to aberrant splicing and predicted premature truncation
additional information
overexpression of AGK sustains constitutive JAK2/STAT3 activation, consequently promoting the cancer stem cell population and augmenting the tumorigenicity of esophageal squamous cell carcinoma cells both in vivo and in vitro. Enzyme knockout by expression of specific RNAi in esophageal squamous cell cancer cells
additional information
TSCCa cells are transfected with lentiviral vectors encoding short hairpin (sh)RNA targeting human AGK for enzyme AGK knockdown. Overexpression of AGK results in upregulation of the protein and mRNA expression levels of cyclin D1, and increases the expression levels of p-Rb, while p21 expression levels are downregulated
additional information
-
TSCCa cells are transfected with lentiviral vectors encoding short hairpin (sh)RNA targeting human AGK for enzyme AGK knockdown. Overexpression of AGK results in upregulation of the protein and mRNA expression levels of cyclin D1, and increases the expression levels of p-Rb, while p21 expression levels are downregulated
additional information
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inactivation of all genes by siRNA transfection, overview
additional information
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homozygous mutation c.3G>A, p.M1I in the gene encoding acylglycerol kinase has been identified in two brothers who presented with vascular strokes, lactic acidosis, cardiomyopathy and cataracts, abnormal muscle cell histopathology and mitochondrial function. One proband had very abnormal mitochondria with citrate synthase crystals visible in electron micrographs, associated with markedly high citrate synthase activity. Homozygous c.979A>T, p.K327* mutation has been identified in a family with four affected members, of which two have been examined. They presented with similar clinical symptoms, but no strokes. Postmortem heart and skeletal muscle tissues showed low complex I, III and IV activities in the heart, but normal in the muscle. Skin fibroblasts showed elevated lactate/pyruvate ratios and low complex I+III activity
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
recombinant human His6-tagged DGK isozyme theta from COS-7 cells by nickel affinity chromatography
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
gene agk, quantitative real-time PCR expression analysis of AGK
gene agk, recombinant overexpression of FLAG-tagged AGK in ECa109 and KYSE510 cells
DNA and amino acid sequence determination and analysis, expression in human PC-3 cells and HEK-293 cells, in mouse NIH 3T3 cells, and in rat RH7777 cells
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recombinant expression of human His6-tagged DGK isozyme theta from vector pSF-CMV-NH2-His-EKT3 in COS-7 cells
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recombinant expression of human p3×FLAG-CMV-DGK isozyme epsilon in COS-7 cells
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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
enzyme expression, at both mRNA and protein levels, are markedly upregulated in glioma tissues compared with non-neoplastic brain tissues
expressions of enzyme is significantly correlated with primary Gleason grade of cancer foci and capsular invasion
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APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
diagnostics
drug development
the enzyme AGK-based mechanism for constitutive activation of JAK2/STAT3 signaling in solid tumors and may represent a therapeutic target
medicine
medicine
diagnostics
early-stage cervical squamous cell cancer (CSCC) patients with high AGK expression level had shorter progress-free survival and overall survival time compared with patients with low AGK expression levels, AGK expression level can be an independent prognostic factor for survival of early-stage CSCC patients
diagnostics
overexpression of acylglycerol kinase is associated with poorer prognosis and lymph node metastasis in nasopharyngeal carcinoma and thus the enzyme has potential as a prognostic factor for overall survival in in nasopharyngeal carcinoma, and for lymph node metastasis in nasopharyngeal carcinoma
diagnostics
the enzyme AGK-based mechanism for constitutive activation of JAK2/STAT3 signaling in solid tumors and may represent a prognostic biomarker. AGK overexpression correlates with progression and poor prognosis in human esophageal squamous cell cancer cells
medicine
identification of a novel autosomal recessive cataract locus on 7q33-q36.1 in a multiplex consanguineous family with isolated congenital cataractl. Mutation is a splice-site mutation in AGK, encoding acylglycerol kinase, which leads to aberrant splicing and predicted premature truncation
medicine
high enzyme expression is significantly associated with the grade of malignancy and poor prognosis in glioma patients. The enzyme is a therapeutic target for treatment of glioma
medicine
-
homozygous mutation c.3G>A, p.M1I in the gene encoding acylglycerol kinase has been identified in two brothers who presented with vascular strokes, lactic acidosis, cardiomyopathy and cataracts, abnormal muscle cell histopathology and mitochondrial function. One proband had very abnormal mitochondria with citrate synthase crystals visible in electron micrographs, associated with markedly high citrate synthase activity. Homozygous c.979A>T, p.K327* mutation has been identified in a family with four affected members, of which two have been examined. They presented with similar clinical symptoms, but no strokes. Postmortem heart and skeletal muscle tissues showed low complex I, III and IV activities in the heart, but normal in the muscle. Skin fibroblasts showed elevated lactate/pyruvate ratios and low complex I+III activity
medicine
-
in membranes from patients with proliferative diabetic retinopathy, vascular endothelial cells express autotaxin and acylglycerol kinase in 16 and 19 out of 22 membranes, respectively. Stromal cells express autotaxin and acylglycerol kinase in 19 and 22 out of membranes, respectively. There are significant correlations between number of blood vessels expressing the panendothelial cell marker CD34 and number of blood vessels and stromal cells expressing autotaxin and acylglycerol kinase. In proliferative diabetic retinopathy membranes, spindle-shaped myofibroblasts expressing alpha-smooth muscle actin co-express autotaxin, acylglycerol kinase and LPA1 receptor
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Spiegel, S.; Milstien, S.
Critical role of acylglycerol kinase in epidermal growth factor-induced mitogenesis of prostate cancer cells
Biochem. Soc. Trans.
33
1362-1365
2005
Homo sapiens
Bektas, M.; Payne, S.G.; Liu, H.; Goparaju, S.; Milstien, S.; Spiegel, S.
A novel acylglycerol kinase that produces lysophosphatidic acid modulates cross talk with EGFR in prostate cancer cells
J. Cell. Biol.
169
801-811
2005
Homo sapiens, Mus musculus
Spiegel, S.; Milstien, S.
Functions of the multifaceted family of sphingosine kinases and some close relatives
J. Biol. Chem.
282
2125-2129
2007
Homo sapiens
Nouh, M.A.; Wu, X.X.; Okazoe, H.; Tsunemori, H.; Haba, R.; Abou-Zeid, A.M.; Saleem, M.D.; Inui, M.; Sugimoto, M.; Aoki, J.; Kakehi, Y.
Expression of autotaxin and acylglycerol kinase in prostate cancer: association with cancer development and progression
Cancer Sci.
100
1631-1638
2009
Homo sapiens
Abu El-Asrar, A.M.; Missotten, L.; Geboes, K.
Expression of autotaxin and acylglycerol kinase in proliferative vitreoretinal epiretinal membranes
Acta Ophthalmol.
90
e84-e89
2012
Homo sapiens
Aldahmesh, M.A.; Khan, A.O.; Mohamed, J.Y.; Alghamdi, M.H.; Alkuraya, F.S.
Identification of a truncation mutation of acylglycerol kinase (AGK) gene in a novel autosomal recessive cataract locus
Hum. Mutat.
33
960-962
2012
Homo sapiens (Q53H12)
Siriwardena, K.; Mackay, N.; Levandovskiy, V.; Blaser, S.; Raiman, J.; Kantor, P.F.; Ackerley, C.; Robinson, B.H.; Schulze, A.; Cameron, J.M.
Mitochondrial citrate synthase crystals: novel finding in Sengers syndrome caused by acylglycerol kinase (AGK) mutations
Mol. Genet. Metab.
108
40-50
2013
Homo sapiens
Sato, Y.; Murakami, C.; Yamaki, A.; Mizuno, S.; Sakai, H.; Sakane, F.
Distinct 1-monoacylglycerol and 2-monoacylglycerol kinase activities of diacylglycerol kinase isozymes
Biochim. Biophys. Acta
1864
1170-1176
2016
Homo sapiens, Mus musculus (Q9ESW4), Rattus norvegicus, Sus scrofa
Chen, X.; Ying, Z.; Lin, X.; Lin, H.; Wu, J.; Li, M.; Song, L.
Acylglycerol kinase augments JAK2/STAT3 signaling in esophageal squamous cells
J. Clin. Invest.
123
2576-2589
2013
Homo sapiens (Q53H12)
Wang, X.; Lin, C.; Zhao, X.; Liu, A.; Zhu, J.; Li, X.; Song, L.
Acylglycerol kinase promotes cell proliferation and tumorigenicity in breast cancer via suppression of the FOXO1 transcription factor
Mol. Cancer
13
106
2014
Homo sapiens (Q53H12)
Liu, G.; Ren, X.; Gao, C.; Zhang, W.
Acylglycerol kinase promotes the proliferation and cell cycle progression of oral squamous cell carcinoma
Mol. Med. Rep.
12
2225-2230
2015
Homo sapiens (Q53H12), Homo sapiens
Zhu, Q.; Cao, S.M.; Lin, H.X.; Yang, Q.; Liu, S.L.; Guo, L.
Overexpression of acylglycerol kinase is associated with poorer prognosis and lymph node metastasis in nasopharyngeal carcinoma
Tumour Biol.
37
3349-3357
2016
Homo sapiens (Q53H12), Homo sapiens
Sun, F.; Xiong, Y.; Zhou, X.H.; Li, Q.; Xiao, L.; Long, P.; Li, L.J.; Cai, M.Y.; Wei, Y.X.; Ma, Y.L.; Yu, Y.H.
Acylglycerol kinase is over-expressed in early-stage cervical squamous cell cancer and predicts poor prognosis
Tumour Biol.
37
6729-6736
2016
Homo sapiens (Q53H12), Homo sapiens
Liu, N.; Wang, Z.; Cheng, Y.; Zhang, P.; Wang, X.; Yang, H.; Liu, H.; Zhang, Y.; Tu, Y.
Acylglycerol kinase functions as an oncogene and an unfavorable prognostic marker of human gliomas
Hum. Pathol.
58
105-112
2016
Homo sapiens (Q53H12), Homo sapiens
Kang, Y.; Stroud, D.A.; Baker, M.J.; De Souza, D.P.; Frazier, A.E.; Liem, M.; Tull, D.; Mathivanan, S.; McConville, M.J.; Thorburn, D.R.; Ryan, M.T.; Stojanovski, D.
Sengers syndrome-associated mitochondrial acylglycerol kinase is a subunit of the human TIM22 protein import complex
Mol. Cell
67
457-470.e5
2017
Homo sapiens (Q53H12), Homo sapiens
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