Data extracted from this reference:
Engineering
additional information
TSCCa cells are transfected with lentiviral vectors encoding short hairpin (sh)RNA targeting human AGK for enzyme AGK knockdown. Overexpression of AGK results in upregulation of the protein and mRNA expression levels of cyclin D1, and increases the expression levels of p-Rb, while p21 expression levels are downregulated
Homo sapiens
Localization
mitochondrion
Homo sapiens
5739
Organism
Homo sapiens
Q53H12
gene agk
Source Tissue
oral squamous cell carcinoma cell
Homo sapiens
Tca-8113 cell
Homo sapiens
tongue epithelial cell line
Homo sapiens
Synonyms
Engineering (protein specific)
additional information
TSCCa cells are transfected with lentiviral vectors encoding short hairpin (sh)RNA targeting human AGK for enzyme AGK knockdown. Overexpression of AGK results in upregulation of the protein and mRNA expression levels of cyclin D1, and increases the expression levels of p-Rb, while p21 expression levels are downregulated
Homo sapiens
Localization (protein specific)
mitochondrion
Homo sapiens
5739
Source Tissue (protein specific)
oral squamous cell carcinoma cell
Homo sapiens
Tca-8113 cell
Homo sapiens
tongue epithelial cell line
Homo sapiens
General Information
malfunction
cell proliferation and cell cycle progression of an established voral squamous cell carcinoma cell, OSCC, cell line are decreased following enzyme AGK knockdown, and are enhanced by enzyme AGK overexpression in vitro. Aberrant AGK expression in OSCC is associated with cell proliferation and cell cycle progression. Knockdown of AGK results in reduced mRNA and protein expression levels of cyclin D1 and p-Rb, whereas the expression levels of p21 are increased
Homo sapiens
physiological function
acylglycerol kinase is a multisubstrate lipid kinase, that is associated with the progression of various types of human cancer, it promotes proliferation and cell cycle progression of oral squamous cell carcinoma. Overexpression of AGK results in upregulation of the protein and mRNA expression levels of cyclin D1, and increases the expression levels of p-Rb, while p21 expression levels are downregulated. The enzyme may promote malignant cancer growth by regulating the expression of cyclin D1 and p21, during the G1-S phase transition
Homo sapiens
General Information (protein specific)
malfunction
cell proliferation and cell cycle progression of an established voral squamous cell carcinoma cell, OSCC, cell line are decreased following enzyme AGK knockdown, and are enhanced by enzyme AGK overexpression in vitro. Aberrant AGK expression in OSCC is associated with cell proliferation and cell cycle progression. Knockdown of AGK results in reduced mRNA and protein expression levels of cyclin D1 and p-Rb, whereas the expression levels of p21 are increased
Homo sapiens
physiological function
acylglycerol kinase is a multisubstrate lipid kinase, that is associated with the progression of various types of human cancer, it promotes proliferation and cell cycle progression of oral squamous cell carcinoma. Overexpression of AGK results in upregulation of the protein and mRNA expression levels of cyclin D1, and increases the expression levels of p-Rb, while p21 expression levels are downregulated. The enzyme may promote malignant cancer growth by regulating the expression of cyclin D1 and p21, during the G1-S phase transition
Homo sapiens
Other publictions for EC 2.7.1.94
737779
Sato
Distinct 1-monoacylglycerol an ...
Homo sapiens, Mus musculus, Rattus norvegicus, Sus scrofa
Biochim. Biophys. Acta
1864
1170-1176
2016
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739741
Zhu
Overexpression of acylglycerol ...
Homo sapiens
Tumour Biol.
37
3349-3357
2016
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739742
Sun
Acylglycerol kinase is over-ex ...
Homo sapiens
Tumour Biol.
37
6729-6736
2016
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739084
Liu
Acylglycerol kinase promotes t ...
Homo sapiens
Mol. Med. Rep.
12
2225-2230
2015
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Wang
Acylglycerol kinase promotes c ...
Homo sapiens
Mol. Cancer
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106
2014
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Siriwardena
Mitochondrial citrate synthase ...
Homo sapiens
Mol. Genet. Metab.
108
40-50
2013
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Acylglycerol kinase augments J ...
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721244
Abu El-Asrar
Expression of autotaxin and ac ...
Homo sapiens
Acta Ophthalmol.
90
e84-e89
2012
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Aldahmesh
Identification of a truncation ...
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Hum. Mutat.
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960-962
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Expression of autotaxin and ac ...
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Critical role of acylglycerol ...
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