EC Number   |
Natural Substrates |
|---|
   2.7.1.94 | ATP + acylglycerol |
- |
| 2.7.1.94 | ATP + diacylglycerol |
- |
| 2.7.1.94 | ATP + monoacylglycerol |
- |
| 2.7.1.94 | more |
lysophosphatidic acid induces the cytokine interleukin-8 correlated with angiogenesis, tumorigenicity, and cancer cell proliferation, the enzyme modulates cross talk with EGFR in prostate cancer cells, enzyme regulates the synthesis of the bioactive phospholipids lysophosphatidic acid and phosphatidic acid, activation of extracellular signal related kinase 1 and 2, thus being involved in pathenogenesis of cancer via enhanced cell proliferation |
| 2.7.1.94 | more |
the enzyme modulates cross talk with EGFR in prostate cancer cells, enzyme regulates the synthesis of the bioactive phospholipids lysophosphatidic acid and phosphatidic acid, activation of extracellular signal related kinase 1 and 2, thus being involved in pathenogenesis of cancer via enhanced cell proliferation |
| 2.7.1.94 | more |
the enzyme plays a critical role in epidermal growth factor-induced mitogenesis of prostate cancer cells via EGF and IFG-II, and lysophosphatidic acid, the first way can be inhibited by enzyme suppression, the second cannot, enzyme function and regulation in initiation and progression of prostate cancer, lysophosphatidic acid enhances surival and suppresses apoptosis by reducing levels of the apoptosis-promoting protein Bax, and is involved in signal transduction pathways, overview |
