Reference on EC 2.7.1.33 - pantothenate kinase and Organism(s) Staphylococcus aureus and UniProt Accession Q6G7I0
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Choudhry, A.E.; Mandichak, T.L.; Broskey, J.P.; Egolf, R.W.; Kinsland, C.; Begley, T.P.; Seefeld, M.A.; Ku, T.W.; Brown, J.R.; Zalacain, M.; Ratnam, K.
Inhibitors of pantothenate kinase: novel antibiotics for staphylococcal infections
Antimicrob. Agents Chemother.
47
2051-2055
2003
Staphylococcus aureus
Virga, K.G.; Zhang, Y.M.; Leonardi, R.; Ivey, R.A.; Hevener, K.; Park, H.W.; Jackowski, S.; Rock, C.O.; Lee, R.E.
Structure-activity relationships and enzyme inhibition of pantothenamide-type pantothenate kinase inhibitors
Bioorg. Med. Chem.
14
1007-1020
2006
Aspergillus nidulans, Escherichia coli, Mus musculus, Staphylococcus aureus
Leonardi, R.; Chohnan, S.; Zhang, Y.M.; Virga, K.G.; Lee, R.E.; Rock, C.O.; Jackowski, S.
A pantothenate kinase from Staphylococcus aureus refractory to feedback regulation by coenzyme A
J. Biol. Chem.
280
3314-3322
2005
Staphylococcus aureus, Staphylococcus aureus RN4220
Hong, B.S.; Yun, M.K.; Zhang, Y.M.; Chohnan, S.; Rock, C.O.; White, S.W.; Jackowski, S.; Park, H.W.; Leonardi, R.
Prokaryotic type II and type III pantothenate kinases: The same monomer fold creates dimers with distinct catalytic properties
Structure
14
1251-1261
2006
Staphylococcus aureus (Q6G7I0), Pseudomonas aeruginosa (Q9HWC1)
Spry, C.; Kirk, K.; Saliba, K.J.
Coenzyme A biosynthesis: an antimicrobial drug target
FEMS Microbiol. Rev.
32
56-106
2008
Escherichia coli, Staphylococcus aureus, Mycobacterium tuberculosis
Hughes, S.J.; Antoshchenko, T.; Kim, K.P.; Smil, D.; Park, H.W.
Structural characterization of a new N-substituted pantothenamide bound to pantothenate kinases from Klebsiella pneumoniae and Staphylococcus aureus
Proteins
82
1542-1548
2014
Klebsiella pneumoniae (B5XYG3), Klebsiella pneumoniae, Staphylococcus aureus (Q6G7I0), Staphylococcus aureus, Staphylococcus aureus MSSA476 (Q6G7I0), Klebsiella pneumoniae 342 (B5XYG3)
Hughes, S.J.; Barnard, L.; Mottaghi, K.; Tempel, W.; Antoshchenko, T.; Hong, B.S.; Allali-Hassani, A.; Smil, D.; Vedadi, M.; Strauss, E.; Park, H.W.
Discovery of potent pantothenamide inhibitors of Staphylococcus aureus pantothenate kinase through a minimal SAR study inhibition is due to trapping of the product
ACS Infect. Dis.
2
627-641
2016
Staphylococcus aureus (A0A167Z3Z6), Staphylococcus aureus, Staphylococcus aureus RN4220 (A0A167Z3Z6)
