Literature summary for 2.7.1.33 extracted from

Choudhry, A.E.; Mandichak, T.L.; Broskey, J.P.; Egolf, R.W.; Kinsland, C.; Begley, T.P.; Seefeld, M.A.; Ku, T.W.; Brown, J.R.; Zalacain, M.; Ratnam, K.
Inhibitors of pantothenate kinase: novel antibiotics for staphylococcal infections (2003), Antimicrob. Agents Chemother., 47, 2051-2055.

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Inhibitors

Inhibitors	Comment	Organism	Structure
pantothenamide, N-substituted	IC50 about 0.0004-0.0016 mM	Staphylococcus aureus

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.027	-	pantothenate	pH 7.5, 25°C	Staphylococcus aureus
0.093	-	ATP	pH 7.5, 25°C	Staphylococcus aureus

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
29100	-	x * 29100, recombinant enzyme, six-His-tagged	Staphylococcus aureus

Organism

Organism	UniProt	Comment	Textmining
Staphylococcus aureus	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
recombinant enzyme, six-His-tagged	Staphylococcus aureus

Reaction

Reaction	Comment	Organism	Reaction ID
ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate	bi bi mechanism	Staphylococcus aureus	a

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + D-pantothenate	-	Staphylococcus aureus	ADP + D-4'-phosphopantothenate	-	?

Subunits

Subunits	Comment	Organism
?	x * 29100, recombinant enzyme, six-His-tagged	Staphylococcus aureus

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0004	0.0016	IC50 about 0.0004-0.0016 mM	Staphylococcus aureus	pantothenamide, N-substituted

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Release 2023.1 (January 2023)