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Information on EC 2.7.1.169 - pantoate kinase

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IUBMB Comments
The conversion of (R)-pantoate to (R)-4'-phosphopantothenate is part of the pathway leading to biosynthesis of 4'-phosphopantetheine, an essential cofactor of coenzyme A and acyl-carrier protein. In bacteria and eukaryotes this conversion is performed by condensation with beta-alanine, followed by phosphorylation (EC 6.3.2.1 and EC 2.7.1.33, respectively). In archaea the order of these two steps is reversed, and phosphorylation precedes condensation with beta-alanine.
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The enzyme appears in viruses and cellular organisms
Synonyms
COG1829, Mhun_0831, PoK, TK2141, TK2141 protein, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + (R)-pantoate = ADP + (R)-4-phosphopantoate
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